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Abstract
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Article Information:
Antibiotic Resistance and Plasmid Profiling of Clinically Significant Vibrio vulnificus Isolated from Coastal Water in Eastern Province of Saudi Arabia
Nasreldin Elhadi
Corresponding Author: Nasreldin Elhadi
Submitted: March 06, 2012
Accepted: March 30, 2012
Published: April 25, 2012 |
Abstract:
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Vibrio vulnificus is an estuarine bacterium that is capable of causing a rapidly fatal infection in
humans. The aim of this study to investigate the occurrence, antibiotic resistance and plasmid profiles of V. vulnificus in Eastern Province of Saudi Arabia coastal water. A total of 10 isolates of V. vulnificus isolated from
coastal water of Arabian Gulf in Eastern Province of Saudi Arabia. All isolates showed a multiple resistance
towards all 10 antibiotics tested. Some of the isolates showed a high resistance to different antibiotics including
gentamicin, ticarcillin, cefaclor, amikacin, augmentin and ampicillin. However, all isolates of V. vulnificus was
susceptible to tetracycline and ampicillin. Overall antibiotics resistance patterns of all isolates were resistant
from 2 to 3 patterns with Multiple Antibiotic Resistance (MAR) index ranging from 0.2 to 0.5 respectively. 4
out of 10 isolates of V. vulnificus harbored plasmid DNA with size ranging from 3.7 to 4.9 kb. These findings
are very important because of the involvement of seawater in transmission of this pathogen to human. V. vulnificus is responsible of causing severe wound infection and is often characterized by necrotizing skin and
soft-tissue infection, primary sepsis in certain high-risk populations, including patients with chronic liver
disease, immunodeficiency, iron storage disorders, end-stage renal disease and diabetes mellitus.
Key words: Antibiotic resistance, coastal water, plasmid DNA, Vibrio vulnificus, , ,
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Abstract
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Cite this Reference:
Nasreldin Elhadi, . Antibiotic Resistance and Plasmid Profiling of Clinically Significant Vibrio vulnificus Isolated from Coastal Water in Eastern Province of Saudi Arabia. British Journal of Pharmacology and Toxicology, (2): 93-97.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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