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Abstract
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Article Information:
Effect of Nano-Particle of Magnesium Oxide on Ketamine-Induced Anesthesia in Rabbit
N. Kavosi, H. Najafzadeh, M. Bavari and A. Esmailirad
Corresponding Author: H. Najafzadeh
Submitted: June 07, 2012
Accepted: June 23, 2012
Published: September 20, 2012 |
Abstract:
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Some studies show magnesium has analgesic effect in some pain models but this evaluation was not
carried on nano-Magnesium Oxide (MgO). Thus, present study was designed to evaluation effect of Mgo nanoparticles
and conventional MgO on ketamine-induced anesthesia in rabbits. At this study, 20 adult rabbits were used
in 4 groups. Ketamine was intrapritonealy injected in all groups and xylazine, MgO nanoparticle and MgO
suspension was administrated 15 min before ketamine injection in 3 last groups. The rectal temperature, respiratory
rate and heart rate were measured before drug administration and during of anesthesia. Duration of anesthesia and
recovery time was recorded. The mean of body temperature and heart rate changed in groups but this change was
not significant except group1 which received only ketamine. The mean of respiratory rate significantly decreased
before and after anesthesia in all groups but this decreasing was greater (nearly 3 fold) in group 2 which received
ketemine and xylazine. Also duration of anesthesia was longer significantly in this group. Thus quality and duration
of ketamine-induced anesthesia did not differ by MgO-nanoparticles with comparison to conventional Mg-O.
Key words: Anesthesia, ketamine, mgo nano-particles, rabbit, , ,
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Abstract
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Cite this Reference:
N. Kavosi, H. Najafzadeh, M. Bavari and A. Esmailirad, . Effect of Nano-Particle of Magnesium Oxide on Ketamine-Induced Anesthesia in Rabbit. Current Research Journal of Biological Sciences, (5): 592-595.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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