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Abstract
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Article Information:
Evaluation of the Suspending Property of Khaya snegalensis Gum in Co-Trimoxazole Suspensions
H.S. Mahmud, A.R. Oyi, T.S. Allagh and M.S. Gwarzo
Corresponding Author: Mahmud Halima. S
Submitted: 2009 October, 08
Accepted: 2009 October, 31
Published: 2010 January, 05 |
Abstract:
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The suspending property of Khaya senegalensis (Family Meliaceae) gum in Co-trimoxazole
suspension was evaluated. The gum obtained from plants grown in Zaria town of northern Nigeria was
processed using standard procedures and its physicochemical properties such as solubility, water sorption, pH
and rheology w ere determined. The gum was used to formulate 4.8% w/v co-trimoxazole suspension in
concentrations of 0.2-5.0% w/v. Acacia senegal gum was used as a standard for comparison. The sedimentation
rates, sedimentation volume, ease of redispersibility and viscosity of the suspension were studied over a period
of 8 weeks. Other properties evaluated were drug release profile and particle size distribution of formulated
suspensions to detect crystal growth. The results show that the sedimentation rate (4x10-4 cm/sec),
sedimentation volume (50ml), degree of flocculation (1.52) and viscosity (118.8 m.pas) at 50 r.p.m are values
obtained for the suspension containing 0.2%w/v khaya gum after 28 days period of storage. Particle size
analysis as an exception, the values of all other parameters obtained for the suspensions containing equivalent
concentrations of acacia gum were lower. The suspensions were stable, pourable and redispersible with no
evidence of crystal growth. The mean particle size of the drug was 3.5 micrometer. The suspension met the
pharmacopoeial requirement for drug release. On the basis of these findings, khaya gum may find application
as suspending agent at 0.2%w/v concentrations.
Key words: Co-Trimoxazole, crystal growth, drug release, khaya senegalensis gum, sedimentation volume, suspension,
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Cite this Reference:
H.S. Mahmud, A.R. Oyi, T.S. Allagh and M.S. Gwarzo, . Evaluation of the Suspending Property of Khaya snegalensis Gum in Co-Trimoxazole Suspensions. Research Journal of Applied Sciences, Engineering and Technology, (1): Page No: 50-55.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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