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Abstract
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Article Information:
Effect of Peristrophe bicalyculata on Blood Pressure, Kidney and Liver Functions of Two Kidney One Clip (2K1C) Hypertensive Rats
A.M. Abdulazeez, C.A. Awasum, Y.S. Dogo and P.N. Abiayi
Corresponding Author: Mansurah Abdulazeez
Submitted: 2010 September, 21
Accepted: 2010 October, 19
Published: 2010 November, 15 |
Abstract:
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The aqueous, butanolic and methanolic fractions of Peristrophe bicalyculata were accessed for their
effect on the arterial blood pressure, liver enzymes and some kidney parameters in hypertensive rats. Forty rats
were divided into nine groups of five rats each: control, hypertensive control, Standard (enalapril 3.8 mg/kg),
methanolic extract (100 and 200 mg/kg), butanolic extract (100 and 200 mg/kg) and aqueous extract (100 and
200 mg/kg). All rats, except control group were made hypertensive using the Goldbatt Two Kidney One Clip
(2K1C) method. Administration of extracts began four weeks after induction of hypertension, and lasted for
two weeks. Blood pressure was determined before inducing hypertension, and then weekly after the induction.
Liver and kidney parameters w ere determined at the end of experiment. Results showed a significant decrease
(p<0.05) in blood pressure of the rats given the standard and all extracts compared to the hypertensive control
group. The serum levels of urea and creatinine, as well as alanine aminotranferase (ALT) activity significantly
decreased in rats given the standard drug, and all extracts, while the butanolic extract did not have effect on
activity of aspartate transaminase and alkaline phosphatase compared to the hypertensive control group.
However, the blood pressure and other parameters determined were significantly (p<0.05) different in rats
treated with the aqueous extract, especially at a higher dose (250 mg/kg) compared to those given the butanolic
and methanolic extracts of the plant. In conclusion, this work has demonstrated the antihypertensive and
hepatoprotective effect of Peristrophe bicalyculata, with the aqueous extract being the most effective.
Key words: Antihypertensive, hepatoprotective, Peristrophe bicalyculata, two kidney one clip hypertensive rats, , ,
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Abstract
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Cite this Reference:
A.M. Abdulazeez, C.A. Awasum, Y.S. Dogo and P.N. Abiayi, . Effect of Peristrophe bicalyculata on Blood Pressure, Kidney and Liver Functions of Two Kidney One Clip (2K1C) Hypertensive Rats. British Journal of Pharmacology and Toxicology, (2): 101-107.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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