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Abstract
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Article Information:
Evaluation of the Effects of Nicotinamide on the Bleomycin-induced Pulmonary Fibrosis in Rat
Peyman Mikaili, Ali Asghar Hemmati, Mohammad Javad Khodayar, Mehri Ghafurian and Iran Rashidi
Corresponding Author: Peyman Mikaili
Submitted: 2011 July, 28
Accepted: 2011 September, 25
Published: 2011 October, 15 |
Abstract:
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Fibrosis is the abnormal production of collagen fibers following tissue damage. This accounts for
the formation of scar tissue. Lung fibrosis is one of the typical ways in which the lung reacts to damaging
stimuli. In this study we tried to investigate the involving phenomena during the process of bleomycin-induced
fibrosis in murine lung. We have evaluated this process at three levels, namely, at (1) cellular level (cells with
contraction activity of pulmonary tissue), (2) intercellular signaling agents (e.g., IL-8, TNF-α, TGF-β), tissue
index factors (collagen, hydroxyproline) and some inorganic elements which may hypothetically be engaged
as efficient enzymatic cofactors (e.g., copper), (3) pathophysiological or exaggerated physiological processes
(inflammation and fibrosis). The pharmacological agent which have been selected for evaluating in this study
is Nicotinamide, which their selection rationale will be discussed in detail separately in the discussion section.
Bleomycin-induced pulmonary fibrosis is a widely used animal model for lung injury and fibrosis. After single
dose instillation of intratracheal bleomycin, the fibrotic responses were studied by biochemical measurement
of collagen deposition and analysis of pathological lung changes in different treatment groups. The results of
this study showed that administrated agents in different doses, had satisfactorily healing effects on fibrosis
process, ranging from good to moderate, through significant decreasing in lung collagen content (p<0.05).
Key words: Bleomycin, L-Hydroxyproline, nicotinamide, pulmonary fibrosis, rat, ,
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Cite this Reference:
Peyman Mikaili, Ali Asghar Hemmati, Mohammad Javad Khodayar, Mehri Ghafurian and Iran Rashidi, . Evaluation of the Effects of Nicotinamide on the Bleomycin-induced Pulmonary Fibrosis in Rat. International Journal of Animal and Veterinary Advances, (5): 330-336.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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