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Abstract
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Article Information:
Comparative Binding Effects of Wheat, Rice and Maize Starches in Chloroquine Phosphate Tablet Formulations
A.R. Oyi, T.S. Allagh and O.J. Olayemi
Corresponding Author: olubunmi olayemi
Submitted: 2009 July, 28
Accepted: 2009 August, 02
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Abstract:
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This study was carried out to compare the binding effects of rice and wheat starches with that of the
official starch; maize starch BP. Granule properties such as angle of repose, moisture content, bulk and tapped
densities, Hausner’s ratio, Carr’s index and tablet properties which included weight uniformity, friability,
disintegration times, and dissolution rates using standard methods. Mucilages of the starches of varying
concentrations of 2.5, 5.0 and 7.5%w/v were used to produce chloroquine phosphate granules by wet
granulation method and compressed into tablets at 4kgF.An increase in binder concentration led to an increase
in crushing strength, decrease in friability and increase in disintegration time of the tablets. Wheat starch
produced the hardest tablets and also the least friable tablets, the longest disintegration time and dissolution
time when compared to maize starch BP. Wheat starch can be a useful binding agent especially where high
bond strength is desired especially in the formulation of chewable tablets and lozenges.
Key words: Binding effect, crushing strength, Wheat, Rice, Maize starch, ,
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Cite this Reference:
A.R. Oyi, T.S. Allagh and O.J. Olayemi, . Comparative Binding Effects of Wheat, Rice and Maize Starches in Chloroquine Phosphate Tablet Formulations. Research Journal of Applied Sciences, Engineering and Technology, (2): Page No: 77-80.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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