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Abstract
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Article Information:
Effects of Aqueous and Ethanolic Extract of Vernonia amygdalina Leaf on the Plasma Lipid Profile and Liver Function Parameters of Normal Rats
C.O. Nwangwu Spencer, J. Josiah Sunday, Usunobun Usunomena, Nwangwu Udoka, A. Akinola Akintola, O. Isreal Ehiremen and Omage Kingsley
Corresponding Author: Usunobun Usunomena
Submitted: 2011 July, 02
Accepted: 2011 August, 08
Published: 2011 September, 10 |
Abstract:
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Many plants with reported medicinal value have been demonstrated to exert a protective effect on
the liver and some, with the ability of lowering the blood lipid level have also been elucidated. This study
shows the effect of ethanolic and aqueous extracts from Vernonia amygdalina on the plasma lipid profile as
well as on the level of the liver biomarker in the plasma of normal rats. The animals were distributed into two
sets of four groups with five animals in each group. Each set had a control group while the other three groups
were administered different concentrations of ethanolic and aqueous extracts from V. amygdalina leaf. The
control groups were administered normal saline and the other groups’ 100, 200 and 300 mg/kg of ethanolic and
aqueous extracts respectively, twice daily for three weeks. The plasma Total Protein (TP), Alkaline Phosphatase
(ALP), Alanine Transaminase (ALT), Aspartate Transaminase (AST), Albumin (ALB) and Bilirubin (BIL)
levels and plasma lipid profile of the rats were evaluated. The aqueous extract of the plant showed a significant
increase in the plasmaconcentration of HDL-C with no significant difference in the plasma TC, LDL-C, VLDLC
and TG levels. Thus, these results suggested that the ethanolic extract from the leaves of V. amygdalina had
a hepatoprotective effect while hypolipidemic effect can be suggested for the aqueous extracts.
Key words: Biomarkers, hepatoprotective, hypolipidemic, Vernonia amygdalina, , ,
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Cite this Reference:
C.O. Nwangwu Spencer, J. Josiah Sunday, Usunobun Usunomena, Nwangwu Udoka, A. Akinola Akintola, O. Isreal Ehiremen and Omage Kingsley, . Effects of Aqueous and Ethanolic Extract of Vernonia amygdalina Leaf on the Plasma Lipid Profile and Liver Function Parameters of Normal Rats. Current Research Journal of Biological Sciences, (5): 504-508.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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