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Abstract
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Article Information:
Effect of Myrtus communis on Healing of the Experimental Skin Wounds on Rats and its Comparison with Zinc Oxide
Ali Rezaie, Daryoush Mohajeri, Behnam Khamene, Mehrdad Nazeri, Ramin Shishehgar and Solmaz Zakhireh
Corresponding Author: Ali Rezaie
Submitted: 2011 November, 09
Accepted: 2011 December, 09
Published: 2012 March, 10 |
Abstract:
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Wound healing in some chronic diseases and disorders has become one of the challenges of medical
science and for this reason using the new compounds to accelerate wound healing is produced will be
welcomed. In the meantime, the Myrtus herb has antibacterial and anti-inflammatory, antiseptic and anticongestive
effects. Based on this information, the purpose of this study was to studying the effect of this plant
extract on process of wound healing. In this study, after induction of anesthesia in 48 male rats weighing 200
to 250 g and approximately one and a half months of age, using a biopsy punch with a diameter of 23 mm
circular wound was created on the dorsal skin region of each of them. Then the rats were divided into four
groups, each groups continued healing process with 5 and 10% extract of Myrtus herb mg/cm 2, 35 dose oncedaily,
eucerin (drugs) and control (distilled water). Test duration was 28 days, wound diameter measurement
using digital image analysis and Histopathological study on days 0, 3, 7, 14, 21 and 28 with biopsy two rats
from each group were took. These rats were removed from the investigation process after obtaining biopsies.
Obtained Results were analyzed with ANOVA and TUKEY test (p<0.05). The results revealed that treatment
with low-dose group of Myrtus herb extract (5%) most shrinkage of wound area and also from the perspective
of Histopathological change. in the second and third week, tissue had better organization than most other groups
(p<0.05), but the group treated with high doses of Myrtus herb extract (10%) had less wound shrinkage and
organization.
Key words: Healing, myrtus communis, rat, skin wounds, zinc oxide, ,
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Cite this Reference:
Ali Rezaie, Daryoush Mohajeri, Behnam Khamene, Mehrdad Nazeri, Ramin Shishehgar and Solmaz Zakhireh, . Effect of Myrtus communis on Healing of the Experimental Skin Wounds on Rats and its Comparison with Zinc Oxide. Current Research Journal of Biological Sciences, (2): 176-185.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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