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Article Information:
Model of Mitogen Activated Protein Kinases for Cell Survival/Death and its Equivalent Bio-circuit
Shruti Jain, Sunil V. Bhooshan and Pradeep K. Naik
Corresponding Author: Pradeep Kumar Naik
Submitted: 2009 September, 17
Accepted: 2009 October, 16
Published: 2010 January, 05 |
Abstract:
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Cell proliferation, differentiation and programmed cell death (apoptosis) are tightly regulated in
healthy tissues by a variety of external signals working via receptors that activate intracellular signal
transduction pathways. Combining engineering analyses and mathematical modeling with intervention and
detection methodologies at the molecular level will allow manipulation of intracellular signal transduction
pathways and therefore rational control of functional processes central to medicine and biotechnology. We have
made computational model for mitogen-activated protein kinase (MAPK), on the basis of that model we have
made the truth tables, Boolean equations and than implement the equations using logic circuits and Bio-circuits
showing cell survival and death.
Key words: Mitogen-activated protein kinase, extracellular-regulated kinase, Jun N-terminal kinases, mitogen- activated protein kinase-activated protein kinase 2, , ,
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Cite this Reference:
Shruti Jain, Sunil V. Bhooshan and Pradeep K. Naik, . Model of Mitogen Activated Protein Kinases for Cell Survival/Death and its Equivalent Bio-circuit. Current Research Journal of Biological Sciences, (1): Page No: 59-71.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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