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Abstract
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Article Information:
Association between Haptoglobin Polymorphism and DNA Damage in Type 2 Diabetes
Marghoob Hasan, Mohammad Al zohairy and Abdelmarouf Mohieldein
Corresponding Author: Marghoob Hasan
Submitted: January 10, 2012
Accepted: February 09, 2012
Published: April 05, 2012 |
Abstract:
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In the present study we aimed to estimate the Oxidative DNA damage in Type 2 diabetic patients
in different haptoglobin polymorphism. Type 2 diabetes is associated with imbalance of antioxidant defense
mechanism, causes alteration in various biomolecules, including DNA. The oxidative DNA damage and its
repair is very crucial in diabetes; the defect in the repair process may lead to cancer among diabetics.
Haptoglobin (Hp) is a polymorphic glycoprotein provides antioxidant function against heam- driven oxidative
stress and has strong association with diabetes and its complication. We investigated the DNA damage
quantification of lymphocytes by AP site (Apurine/Apyrimidine site) counting and that correlated with Hp
polymorphism among type 2 diabetics. The Hp1-1 phenotype had the least DNA damage than HP 2-1 & HP
2-2; this indicates that Hp alleles differ in their protective effects against oxidative damage, and HP 1-1 was
the most protective.
Key words: Antioxidant, AP site counting, DNA damage, haptoglobin phenotypes, oxidative stress, type 2,
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Cite this Reference:
Marghoob Hasan, Mohammad Al zohairy and Abdelmarouf Mohieldein, . Association between Haptoglobin Polymorphism and DNA Damage in Type 2 Diabetes. Current Research Journal of Biological Sciences, (3): 284-289.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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