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Abstract
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Article Information:
Induced Histological Features of Hypoxia-Ischaemia in the Brain of Rats Fed with Diet Containing Yaji: The Complex Nigerian Meat Sauce
A.O. Nwaopara, C.I.P. Anibeze and F.C. Akpuaka
Corresponding Author: Nwaopara, Anthony Obioma
Submitted: 2009 November, 09
Accepted: 2009 November, 18
Published: 2010 January, 05 |
Abstract:
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Yaji is a complex mixture of groundnut cake powder, additives, spices and salt. The production and
consumption of Yaji is not regulated despite the potential health hazards of its numerous active principles. This
fact has been the basis for several scientific investigations aimed at determining the effect of Yaji on body organs. The present histological study is intended to determ ine the effects of Yaji consumption on the blood supply of the brain. Eighteen weeks old white albino rats of an average weight of 170g were used for this study.
They were divided into eight groups (A – H) of three subgroups each. Subgroup 1, 2 and 3 represents
experimental periods of 2 weeks, 4weeks, and 6 weeks respectively. Group A rats served as control and were
fed with normal feed (growers mash) only, while Groups B – H served as the test groups and were fed with
normal feed plus graded levels of Yaji (B, 10%; C, 20%; D, 30%; E, 40%; F, 50%; G, 60%; and H, 70%). At
the end of the respective experimental periods, test group rats were sacrificed in order to harvest the brain
tissues for tissue processing. The stained brain tissue micrographs showed vascular changes (fat embolism and
thrombosis) and cerebral infarction in the brain of test rats in group B2 (4weeks; 10%), B3 (6weeks; 10%) and
F3 (6 weeks; 50%). Our findings suggest that at sustained high dose consumption, Yaji has the capacity to
induce cerebrovascular changes with its attendant consequences such as hypoxia – ischaemia and subsequently,
brain tissue necrosis.
Key words: Brain, cerebral infarction, fat embolism Suya, thrombosis, Yaji, ,
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Cite this Reference:
A.O. Nwaopara, C.I.P. Anibeze and F.C. Akpuaka, . Induced Histological Features of Hypoxia-Ischaemia in the Brain of Rats Fed with Diet Containing Yaji: The Complex Nigerian Meat Sauce. Research Journal of Applied Sciences, Engineering and Technology, (1): Page No: 67-72.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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