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Abstract
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Article Information:
Histopathological Comparison of the Effect of Normal Saline and Silver Sulfadiazine on Scorch Healing in Rats
Daryoush Mohajeri, Mehran Mesgari, Yousef Doustar and Mehrdad Nazeri
Corresponding Author: Daryoush Mohajeri
Submitted: 2011 November, 12
Accepted: 2011 December, 20
Published: 2012 March, 10 |
Abstract:
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Skin burn is one of the most common complications throughout the world. Silver sulfadiazine (SSD)
is used as a choice treatment in many superficial burn wounds. But, some studies have questioned its efficacy.
The main objective of this study was to compare the effects of Normal Saline (NS) and SSD on healing of
superficial skin burn wounds in rats. Male Wistar rats were randomly assigned in two different groups including
treatment and control, with 20 animals each. After sedation, a type II skin burn wound in the shape of a 1-cm
diameter circle was created in the dorsum of the rats with boiled water contact. In treatment group, NS and in
control group, SSD was used topically for care. Diameter of the wound as well as the hair growing grade was
determined on days 3, 7 and 14 post-intervention. In each step of the experiment, histopathological sections
were prepared; thereafter reepithelialization and alleviation of inflammation at the healing site of burn wound
were assessed. Statistically, the data obtained were compared between the groups. There were no significant
differences between the groups regarding the mean diameter of the wound on days 3 and 14 (p = 0.089, p =
0.495). The mean diameter of the wound was significantly lower in treatment (NS) group on day 7 (p<0.001).
There were no significant differences between the groups regarding the mean hair growth score in different
stages of the experiment (p = 1, p = 0.647, p = 0.805). Histopathologically, there were no significant difference
between these two experimental groups from the view point of reepithelialization and alleviation of
inflammation at the healing site of burn wound. The results of this study showed that NS equals with SSD in
improvement of superficial skin burn wounds healing in the rats; and after the randomized clinical trials, it can
be used in treatment of superficial skin burn wounds in human bodies.
Key words: Healing, normal saline, rat, scorch, silver sulfadiazine, ,
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Cite this Reference:
Daryoush Mohajeri, Mehran Mesgari, Yousef Doustar and Mehrdad Nazeri, . Histopathological Comparison of the Effect of Normal Saline and Silver Sulfadiazine on Scorch Healing in Rats. Current Research Journal of Biological Sciences, (2): 192-197.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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