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Abstract
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Article Information:
Relationship Between Helicobacter pylori (H. pylori) Infection and Multiple Sclerosis (MS) in Southeast of Iran
Nima Sanadgol, Ebrahim Shahraki and Jasem Estakhr
Corresponding Author: Nima Sanadgol
Submitted: February 09, 2012
Accepted: March 01, 2012
Published: July 10, 2012 |
Abstract:
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Helicobacter pylori (H. pylori) are one of the most common, well-known pathogenic agents in the
development of peptic ulcers. Some investigators have shown a relationship between H. pylori and Multiple
Sclerosis (MS). However, this relationship is controversial. The aim of this study was to determine the
association between H. pylori infection and MS. In a prospective case-control study, we studied 78 patients with
MS and 123 Healthy Blood Donors (HBDs) for bacterial DNA detection and antibody assay. DNA extracted
from samples (serum and saliva) and Real-time PCR was employed to detection of H. pylori genome. The
present of anti H. pylori CagA and VacA Immunoglobulin G (IgG) were measured in serum by Western blot
technique. We found H. pylori DNA in both samples of the 32.05% (25/78) and 32.52% (40/123) of patients
and HBDs respectively (p = NS). Furthermore, anti H. pylori IgG for both antigens were detected in 21.95%
(27/123) of HBDs in contrast with 25.64% (20/78) of patients (p = NS). Moreover, genome copy number of
H. pylori was not significantly change in patients (140 copies/mL) and HBDs (147 copies/mL). We didn’t see
significant correlation between H. pylori infection in both groups, But H. pylori CagA/VacA-IgG was found
in patient quite more than HBDs (p<0.05) and this patients showed more positively for serum H. pylori genome.
Although, these results indicate a lack of connection between the Helicobacter pylori infection and multiple
sclerosis, the role of immune response against H. pylori in the modulation of MS requires further study.
Key words: H. pylori, MS, real time-PCR, western blot, , ,
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Cite this Reference:
Nima Sanadgol, Ebrahim Shahraki and Jasem Estakhr, . Relationship Between Helicobacter pylori (H. pylori) Infection and Multiple Sclerosis (MS) in Southeast of Iran. Current Research Journal of Biological Sciences, (4): 422-426.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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