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Abstract
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Article Information:
Efficacy of Di-n-octyl Phthalate Anti Venom Isolated from Ceiba pentandra Leaves Extract in Neutralization of Echis ocellatus Venom
S. Ibrahim, J.A. Nok, M.S. Abubakar and S. Sarkiyayi
Corresponding Author: S. Ibrahim
Submitted: January 02, 2012
Accepted: March 15, 2012
Published: August 01, 2012 |
Abstract:
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The aim of the study is to investigate the efficacy of Di-n-octyl phthalate isolated from Ceiba
pentandra leaves extract for its anti Echis ocellatus venom properties. The leaves of Ceiba pentandra was
extracted with aqueous methanol, partitioned on column chromatography and subjected to TLC and preparative
TLC. The isolate was tested for its anti venom activity and submitted to IR and GCMS for structural
elucidation. Our findings revealed that the isolate was biologically active in inhibiting PLA2 activity in a dose
dependent manner. The IR analysis showed that the isolate has a carbonyl functional group and aromatic ring
and the GCMS analysis revealed that the compound isolated was Di-n-octyl phthalate with molecular weight
391. The inhibitor (Di-n-octyl phthalate) isolated during this research might become a highly effective
therapeutic agent for the reducing of snake bite envenomation. The relevance of these findings would be of
importance in the area of development of anti snake bite drugs that are going to be effective, cheap, accessible
and less allergic plant compound that can be scientifically explored.
Key words: Ceiba pentandra, di-n-octyl phthalate, Echis ocellatus, PLA2 activity, , ,
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Cite this Reference:
S. Ibrahim, J.A. Nok, M.S. Abubakar and S. Sarkiyayi, . Efficacy of Di-n-octyl Phthalate Anti Venom Isolated from Ceiba pentandra Leaves Extract in Neutralization of Echis ocellatus Venom. Research Journal of Applied Sciences, Engineering and Technology, (15): 2382-2387.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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