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Abstract
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Article Information:
The Effect of Changes in Oxygen Tension During Fracture Repair on Mesenchymal Stem Cell and Bone Activities
S. Gidado, W.S. Khan and D.R. Marsh
Corresponding Author: Wasim Khan
Submitted:
Accepted:
Published: |
Abstract:
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Fracture healing is a complex physiological process that results in regenerative of bone. This study
looks in greater detail into the effect of oxygen tension, one of the multiple parameters that successful fracture
healing depends on. A summary of the biology of bone and bone repair is described before delving into the
effect of oxygen tension on fracture healing. The preponderance of evidence appears to suggest that hypoxia
taken in isolation promotes the up regulation of several signalling molecules involved in the fracture repair
cascade in In vitro studies by many cells especially osteoblasts, however there is some suggestion to the
contrary. The influence of oxygen tension on fracture healing will continue to be investigated especially how
HIF-1 affects the various cells responsible for this regenerative process.
Key words: , , , , , ,
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Abstract
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Cite this Reference:
S. Gidado, W.S. Khan and D.R. Marsh, . The Effect of Changes in Oxygen Tension During Fracture Repair on Mesenchymal Stem Cell and Bone Activities. Current Research Journal of Biological Sciences, (1): Page No: 7-10.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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