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Abstract
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Article Information:
Litter Size, Sex Ratio and Some Liver Biomarkers in Sprague-Dawley Rats Recovering From Exposure to Ethanol Extract of Lepidagathis alopecuroides
Eme Efioanwan Orlu and Oguguo K. Ogbalu
Corresponding Author: Eme Efioanwan Orlu
Submitted: July 13, 2012
Accepted: August 15, 2012
Published: September 20, 2012 |
Abstract:
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This study was aimed at assessing reproductive recovery of Sprague-Dawley rat after cessation of
treatment with ethanol extract of Lepidagathis alopecuroides (Vahl). Thirty sexually mature male Sprague-Dawley
rats were previously divided into six groups (A-F). Groups B-F administered ethanol extract of Lepidagathis
alopecuroides orally at a daily dose of 50, 100, 150, 200 and 250 mg/kg body weight, respectively, for 35 days were
tested for fertility following 35 days recovery period. Each male was kept with two mature females for mating
purposes and observed. Upon delivery the sex, litter sizes and weight of pups were taken. Results showed significant
(p<0.01) increase in litter size in the 35 days recovery groups. The mean birth weight and the weaning weights of
the pups were comparable (p>0.05) to the control group. There was small but non-significant (p>0.05) increase in
Sex ratio in the recovery group and no morphological abnormalities were observed in the pups. Liver function
Transaminases (Alanine Transaminase ALT, Aspartate Transaminase AST) elevated during the treatment period
reduced to control levels. Phosphatases (Alkaline Phosphatase ALP, Acid Phosphatase) assessed after the recovery
period were also reduced to control values 35days after cessation of treatment. Similar reversion to control values
was observed in serum total protein, albumin, creatinine, urea and total bilirubin. This investigation reveals that the
toxic and reproductive inhibitory effect of Lepidagathis alopecuroides is reversible in mammals after cessation of
the treatment. Chronic use of the extract is not recommended. However, caution in the use of the plant as an herbal
medicine is advocated.
Key words: Birth weight , litter size, plant extract, rat, sex ratio, weaning weight,
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Cite this Reference:
Eme Efioanwan Orlu and Oguguo K. Ogbalu, . Litter Size, Sex Ratio and Some Liver Biomarkers in Sprague-Dawley Rats Recovering From Exposure to Ethanol Extract of Lepidagathis alopecuroides. Current Research Journal of Biological Sciences, (5): 643-648.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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