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Abstract
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Article Information:
All Serotypes of Dengue Viruses Circulating in Kuala Lumpur, Malaysia
M.H. Chew, M.M. Rahman, J. Jelip, M.R. Hassan and I. Isahak
Corresponding Author: Muhammad Hasyim
Submitted: 2011 December, 22
Accepted: 2012 January, 21
Published: 2012 March, 10 |
Abstract:
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Dengue is a severe disease caused by dengue virus (DENV), transmitted to human being by infected
Aedes mosquitoes. It is a major public health concern in Southeast Asia due to its fatality in the form of
Dengur Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). The objective of the study was to
isolate and identify dengue virus serotypes prevalent in endemic areas of Kuala Lumpur and Selangor in
Malaysia by virus culture, indirect immunoflurecent assay and molecular techniques. A total number of 232
sera samples were obtained from patients with clinical manifestations of dengue fever reported to University
Kebangsaan Malaysia Medical Centre (UKMMC). The sera samples collected, were analyzed for IgM/IgG
detection for the assessment of primary and secondary dengue fever, propagation in cell-line C36/36, Indirect
Immunoflurecent Assay (IFA) and RT-PCR. The study confirmed 46 dengue cases where 15 (32.61%) were
dual infections with DENV-1 and DENV- 4, 12 (26.09%) dual infections with DENV-3 and DENV-4, and
11 (23.91%) were dual infection with DENV-2 and DENV-4. Only 1 (2.17%) was dengue infection with
DENV-3 and 7 (15.22%) were with DENV-4. Dengue serotype 4 was the most common serotype identified in
the present study .The highest number of dengue cases detected in Cheras, Kuala Lumpur where all 4 types of
dengue virus were prevalent. All serotypes of dengue viruses circulation only in Kuala Lumpur and Selangor
Malaysia, needs further strengthening of the dengue preventive measure in the city areas and in the country.
Key words: Dengue fever, dengue hemorrhagic fever, DENV, RT-PCR, serotypes, ,
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Cite this Reference:
M.H. Chew, M.M. Rahman, J. Jelip, M.R. Hassan and I. Isahak, . All Serotypes of Dengue Viruses Circulating in Kuala Lumpur, Malaysia. Current Research Journal of Biological Sciences, (2): 229-234.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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