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Abstract
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Article Information:
Effects of Pre-induction Administration of Allium Sativum on Some Biochemical Parameters in Alloxan Induced Diabetic Rats
Ojo Rotimi Johnson, Memudu Adejoke Elizabeth, Akintayo Christopher Oloruntoba and Akpan Idongesit Sunday
Corresponding Author: Ojo Rotimi Johnson
Submitted: April 07, 2012
Accepted: April 30, 2012
Published: December 01, 2012 |
Abstract:
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The aim of the present study was to investigate the effects of pre- and post- administration of garlic
extract on serum glucose and some biochemical parameters in alloxan-induced diabetic rats to show the
preventive and ameliorating effects in alloxan induced-diabetic rats. Rats were divided into 4 groups; normal
control rats, diabetic control rats, diabetic rats post-treated with garlic extract and rats pre-treated with garlic
extract before induction. Garlic extract was administered orally for 2 weeks to post-treated rats and 3 weeks
to pre-treated rats and they were compared with the normal and diabetic groups, respectively. Serum glucose
was reduced significantly in both post-treated and pre-treated groups. The post-treatment with garlic extract
reduced serum cholesterol, but pre-treatment with garlic extract produced significant change compare to the
diabetic control. The serum creatinine and urea levels were significantly reduced in post-treated group and pretreated
group compare to the diabetic control group. It is concluded that the consumption of garlic produced
a significant hypoglycaemic and hypolipidemic effects in diabetic rats and also, garlic is capable of protecting
the liver and the kidney functions in alloxan-induced diabetic rats as shown in the activities of serum enzymes
and other biochemical parameters examined.
Key words: Alloxan , diabetes, garlic, pre-induction, pre-treatment, serum enzymes, serum enzymes
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Cite this Reference:
Ojo Rotimi Johnson, Memudu Adejoke Elizabeth, Akintayo Christopher Oloruntoba and Akpan Idongesit Sunday, . Effects of Pre-induction Administration of Allium Sativum on Some Biochemical Parameters in Alloxan Induced Diabetic Rats. Research Journal of Applied Sciences, Engineering and Technology, (23): 5129-5135.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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