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Abstract
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Article Information:
Effect of Aqueous Garlic (Ag) Extract on Aspirin Induced Gastric Mucosal Lesion in Albino Wistar Rats
M.A. Mabrouk, F.I. Nnawodu, Y. Tanko, F. Dawud and A. Mohammed
Corresponding Author: Mohammed Aliyu
Submitted: 2009 June, 09
Accepted: 2009 July, 15
Published: |
Abstract:
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The aim of this study was to evaluate the effect of aqueous garlic (AG) extract on aspirin induced
gastric mucosal lesion. It was carried out on 72 albino Wistar rats. Animals were divided into two groups.
Gastric ulcer group (n=36) and gastric secretion group (n=36). Each group was subdivided into control (n=16)
and study groups (n=18). Control group was further subdivided into 3 subgroups including (1) Oral distilled
water subgroup (n=6); (2) Oral aspirin (150mg/kg) subgroup (n=6) and (3) Oral AG extract (150mg/kg)
subgroup (n=6).The study group was also subdivided into (1) Oral aspirin (150mg/Kg) + AG extract
(150mg/kg) subgroup(n=6); (2) Oral aspirin (150mg/Kg) + AG extract(300mg/kg) subgroup(n=6) and (3)Oral
aspirin(150 mg/kg) + Cemitidine(50mg/kg) I.P subgroup((n=6).All groups were fasted for 36 hours before
pyloric ligation. Gastric secretions were collected, centrifuged and analysed.Gastric ulcer parameters were also
studied for gastric ulcer group. There was significant decrease(p<0.05) of titratable acidity and total acid output
in aspirin(150mg/Kg) + AG (150mg/Kg) and aspirin(150mg/Kg) + AG (300mg/kg) when compared with
aspirin(150mg/Kg) alone group. Also there was significant decrease (p<0.05) in ulcer index and ulcer score
in both groups than aspirin alone group. In comparison between garlic groups and cemitidine group there was
more decrease in these parameters in cemitidine groups than garlic group. It seem s likely that AG extract
offered protective effects on aspirin induced gastric mucosal lesion.
Key words: Antioxidant,, garlic extract,, gastric secretion,, gastric ulcer, , ,
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Cite this Reference:
M.A. Mabrouk, F.I. Nnawodu, Y. Tanko, F. Dawud and A. Mohammed, . Effect of Aqueous Garlic (Ag) Extract on Aspirin Induced Gastric Mucosal Lesion in Albino Wistar Rats. Current Research Journal of Biological Sciences, (2): Page No: 15-19.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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