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Abstract
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Article Information:
Evaluation and Screening of Nitrogen Source for L-asparaginase Production by Aspergillus terreus MTCC 1782 using Latin Square Design
G. Baskar and S. Renganathan
Corresponding Author: G. Baskar
Submitted: 2009 Sep., 02
Accepted: 2009 Sept., 14
Published: |
Abstract:
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The manufacture of enzymes, like L-asparaginase with less adverse effects in the treatment of cancer is an important facet of pharmaceutical industry. Yeast and Filamentous fungi are commonly reported in scientific literature to produce L-asparaginase with less adverse effects than prokaryotic microorganisms. In the present study Latin square design was used to examine the effect of L-proline, L-glutamic acid and Sodium nitrate as nitrogen sources on production of extracellular L-asparaginase by Aspergillus terreus MTCC 1782 in order to obtain the best nitrogen source in shake culture fermentation. The experimental values of L-asparaginase activity were subjected to statistical analysis and statistical significance of the nitrogen sources was studied for the Latin-Square Design using Dataplot software. It was found that L-proline as a best nitrogen source for the production of L-asparaginase by Aspergillus terreus MTCC 1782 for maximum L-asparaginase activity.
Key words: Bioprocess, latin square design, optimization, shake culture fermentation, , ,
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Cite this Reference:
G. Baskar and S. Renganathan, . Evaluation and Screening of Nitrogen Source for L-asparaginase Production by Aspergillus terreus MTCC 1782 using Latin Square Design. Research Journal of Mathematics and Statistics, (2): Page No: 55-58.
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ISSN (Online): 2040-7505
ISSN (Print): 2042-2024 |
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