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Abstract
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Article Information:
Antidepressant Effects of Noni Fruit and its Active Principals
Shixin Deng and Brett J. West
Corresponding Author: Shixin Deng
Submitted: 2011 February, 24
Accepted: 2011 March, 26
Published: 2011 April, 20 |
Abstract:
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The antidepressant effects of Morinda citrifolia (noni) fruit extracts were investigated in vitro with
the Monoamine Oxidase (MAO) A and B bioassays. The ethyl acetate extract of freeze-dried noni fruit powder
inhibited MAO-A and B enzymes 78 and 49%, respectively. A phytochemical study of the most active extract
led to the isolation of nine compounds. Among these, three principles including two flavonoids, kaempferol
and quercetin, as well as one lignan, (+)-3,4,3',4'-tetrahydro-9,7'α-epoxylignan-7α,9'-lactone, were found to
be potent MAO-A and B inhibitors. These findings indicate that noni fruit is a natural MAO-A and MAO-B
inhibitor, involving a synergistic effect from multiple active components.
Key words: Active compounds, antidepressant, MAO-A & B, Morinda citrifolia, noni, ,
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Abstract
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Cite this Reference:
Shixin Deng and Brett J. West, . Antidepressant Effects of Noni Fruit and its Active Principals. Asian Journal of Medical Sciences, (2): 79-83.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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