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Abstract
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Article Information:
Phytochemical Screening of the Dried Leaf Extract of Cnidoscolus aconitifolius and Associated Changes in Liver Enzymes Induced by its Administration in Wistar Rats
J.C. Mordi and M.A. Akanji
Corresponding Author: J.C. Mordi
Submitted: 2011 October, 28
Accepted: 2011 December, 09
Published: 2012 March, 10 |
Abstract:
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Cnidoscolus aconitifolius (Euphorbiaceae) is used traditionally for the treatment of many disease
conditions in Nigeria. So far, no safety studies have been carried out with this plant. This study attempts to
determine the phytochemical constituents of the plants leaf extract as well as examination of its effect on some
liver enzymes. Results show no significant difference (p>0.05) between the control and the Cnidoscolus
aconitifolius administered rats (at doses of 100, 300, 500 and 800 mg/kg body weight for 6 weeks) with respect
to the changes in body weight as well as in the liver enzymes analyzed in serum. The non-toxic effect of the
aqueous and ethanolic plant extracts were also confirmed by histological studies. Phytochemical investigation
of both the (dry) aqueous and ethanolic leaf extracts of Cnidoscolus aconitifolius shows the presence alkaloids,
tannins, phlobatannin, saponin and phenols. Phlobatannin and saponin were found in appreciable amounts in
the aqueous extract than the ethanolic extract. While cardiac glycosides were only positive and present in the
aqueous extract only. The ethanolic extract was found to contain flavonoids, anthraquinones, steroids, terpenes.
These were not found in the aqueous extract. From this study, it may be concluded that Cnidoscolus
aconitifolius showed absence of cumulative toxicity as reflected by the non-significant changes in the
parameters studied as well as from the results of the histological investigation.
Key words: Cnidoscolus aconitifolius, flavonoid, liver, phenol, saponins, Liver, Enzymes, Saponins, Cnidoscolus aconitifoli, Liver, Enzymes, Saponins, Cnidoscolus aconitifoli
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Cite this Reference:
J.C. Mordi and M.A. Akanji, . Phytochemical Screening of the Dried Leaf Extract of Cnidoscolus aconitifolius and Associated Changes in Liver Enzymes Induced by its Administration in Wistar Rats. Current Research Journal of Biological Sciences, (2): 153-158.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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