Research Article | OPEN ACCESS
Purple Sweet Potato Anthocyanin Inhibits the Proliferation of Human Retinal Pigment Epithelial Cell by Blocking Cell Cycle and Inducing Apoptosis
Xiaoling Lu, MinSun, Lei Hao, Tao Wu, Huanjiao Zhao and Chao Wang
Key Laboratory of Food Nutrition and Safety of the Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin, China
Advance Journal of Food Science and Technology 2016 8:561-569
Received: August 5, 2015 | Accepted: September 3, 2015 | Published: July 15, 2016
Abstract
Purple Sweet Potato Anthocyanin (PSPA), a class of naturally occurring anthocyanins derived from purple sweet potato storage roots, possesses unique color and multiple bioactivities. This study investigated the anti-proliferative effect of PSPA in human Retinal Pigment Epithelial (RPE) cells, the proliferation of which accounts for Proliferative Vitreoretinopathy (PVR). Blueberry Anthocyanin (BBA) was used as a contrast. PSPA and BBA inhibited RPE proliferation time-and dose-dependently through blocking the cell cycle in G0/G1 phase and inducing apoptosis via ROS accumulation, DNA damage and caspase 3/7 activation. Meanwhile, PSPA showed stronger potential than BBA in inhibiting RPE growth. Hence, we highlighted the importance of dietary supplementation of anthocyanins in PVR prevention and the application of PSPA in health industry.
Keywords:
Apoptosis, cell cycle, proliferation, purple sweet potato anthocyanin, retinal pigment epithelial,
| |
