Abstract

The present research gives an insight into astaxanthin production, as well as transcription differences of four key carotenogenic genes, in Xanthophyllomyces dendrorhous when cultured with various carbon sources and soybean oil as co-substrates. Glucose was found to be the carbon source with best culture growth and astaxanthin production and the addition of 2% (v/v) soybean oil resulted in even higher astaxanthin producing. In addition, four carotenogenic genes encoding geranylgeranyl diphosphate synthase (crtE), phytoene desaturase (crtI), phytoene synthase lycopene cyclase (crtYB) and astaxanthin synthetase (ast), respectively, were demonstrated to be associated with different transcription levels under various substrates. The present study suggests the effectiveness of manipulating the metabolic regulation by using different carbon sources, in order to improve the production of astaxanthin.

Keywords:

Astaxanthin, carbon source, carotenogenic genes, Xanthophyllomyces dendrorhous,

References

Competing interests

The authors have no competing interests.

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Copyright

The authors have no competing interests.