Research Article | OPEN ACCESS
Research on Inhibitory Effect of Momordica charantia L. Polyphenol on Vascular Endothelial Intercellular Adhesion Molecular-1 (ICAM-1) mRNA Abnormal Expression
1Xuezheng Huang, 2Miaochao Chen and 3Peilong Xu
1School of Civil Engineering, Nanyang Institute of Technology, Nanyang, No. 80, Changjiang Road, Nanyang 473004, P.R. China
2Chaohu College, Chaohu 238000, P.R. China
3Qingdao University, Qingdao 266071, P.R. China
Advance Journal of Food Science and Technology 2013 8:1096-1099
Received: April 22, 2013 | Accepted: May 18, 2013 | Published: August 05, 2013
Abstract
The study held a research on the anti-oxidative damage effect and mechanism of Momordica charantia L. Polyphenol from gene level. Method: it tested the influence of Momordica charantia L. Polyphenol to human umbilical veins blood vessel endothelial cell strain (CRL-1730) ICAM-1 mRNA cellular expression caused by oxidative damage with RT-PCR method. Result: the experimental result indicated that the luminance and area values of electrophoretic band of 4, 5, and 6 with different doses of Momordica charantia L. Polyphenol for protection were all lower than positive control group, while higher than normal control group, furthermore, it presented a state that be increasing with the augment of Momordica charantia L. Polyphenol dose. The degree of protection of the three dose groups, high, medium and low, were separately 91.1, 82.7 and 37.3%, respectively after making a comparison in each group. Conclusion: Momordica charantia L. Polyphenol can inhibit cell adhesion molecular-1 expression and make a protective effect to vascular endothelial cell damage.
Keywords:
Momordica charantia L. Polyphenol (MCLP), oxidative damage, vascular endothelial cell,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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