Research Article | OPEN ACCESS
Hydrolysable Tannins and Related Compound having Cytotoxic Activity of Geranium Wilfordii Maxim
1, 2Ping Li, 1Luosha Zhao, 1Youyou Du, 2Yinman Feng and 2Yanhong Li
1Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2Academician Expert Workstation of Zhengzhou Health Department, Zhengzhou, China
Advance Journal of Food Science and Technology 2013 3:255-257
Received: September 03, 2012 | Accepted: October 19, 2012 | Published: March 15, 2013
Abstract
In order to exhibit moderate cytotoxic activity toward the human tumor cell lines including A-549, SK-OV-3, HT-1080, K562 and S180, the cytotoxicity-directed fractionation of Me OH extract of Geranium wilfordii Maxim led to the isolation of three hydrolyzed tannins and a related compound, Gallic acid (I), 1, 2, 3, 4, 6-penta-O-galloyl-&beta-D-glucopyranose (ll), chebulagic acid (Ⅲ) and chebulinic acid (IV), as active principles. They were shown to exhibit moderate cytotoxicity against cultured human tumor cell lines including A549, SK-OV-3, HT-1080, K562 and S180 in vitro.
Keywords:
Antitumor, cytotoxicity, gallic acid, geranium wilfordii maxim,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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