Research Article | OPEN ACCESS
Pancreatic Lipase Inhibitory Effects of Mangosteen Pericarps
Xinjie Lin, Baojun Xu and Liu Rui
Food Science and Technology Program, Beijing Normal University-Hong Kong
Baptist University United International College, Zhuhai, Guangdong, 519085, China
Advance Journal of Food Science and Technology 2014 3:284-291
Received: September 18, 2012 | Accepted: October 30, 2012 | Published: March 10, 2014
Abstract
Pancreatic lipase plays a key role in the digestion and absorption of lipids, inhibition of Pancreatic Lipase (PL) is considered as a new approach to obesity treatment. The objective of the present study was to find PL inhibitors from natural food sources. Eighteen natural food products sampled from local supermarkets in Zhuhai were tested for PL inhibitory activity using a copper-soap photometric method. Among the samples tested, the crude extracts from mangosteen pericarp, lemon pulp, celery, cucumber and dry longan were found to be able to suppress the PL activity to different extents, while dry red chili, fresh green chili and dry clove exhibited a promotion effect on the PL. Shiitake mushroom, green bell pepper, lemon peel and spices (ginger, oregano leaf, bay leaf, cinnamon and dry tangerine) showed no significant influence either on the inhibition or promotion. The crude extract of mangosteen pericarp was further fractioned to trace active fractions. It was found that the n-butanol fraction was the major contributor to the PL-inhibitory effect of mangosteen pericarp and the inhibition rate was 43.9% at the concentration of 1 mg/mL, the IC50 value was 0.918 mg/mL. Mangosteen pericarp is worthy of utilization as functional food constituents for the prevention and treatment of obesity.
Keywords:
Mangosteen pericarp, natural food products, obesity, pancreatic lipase,
References
-
Atawodi, S.E., J.C. Atawodi, B. Pfundstein, B. Spiegelhalder, H. Bartsch and R. Owen, 2011. Assessment of the polyphenol components and in vitro antioxidant properties of Syzygium aromaticum (L). Merr. Perry. Electron. J. Environ. Agric. Food Chem., 10(3): 1970-1978.
- Ballinger, A. and S.R. Peikin, 2002. Orlistat: Its current status as an anti-obesity drug. Eur. J. Pharmacol., 440: 109-117.
CrossRef
- Birari, R.B. and K.K. Bhutani, 2007. Pancreatic lipase inhibitors from natural sources: Unexplored potential. Drug Discov. Today, 12: 879-889.
CrossRef PMid:17933690
- Chaput, J.P., S. St-Pierre and A. Tremblay, 2007. Currently available drugs for the treatment of obesity: Sibutramine and orlistat. Mini Rev. Med. Chem., 7: 3-10.
CrossRef PMid:17266632
-
Gondoin, A., D. Grussu, D. Stewart and G.J. McDougall, 2010. White and green tea polyphenols inhibit pancreatic lipase in vitro. Food Res. Int., 43(5): 1537-1544.
CrossRef
- Khan, J.A.J., 2003. Preliminary study on the biological and the biochemical effects of cloves spice. J. King Abdulaziz Univ., Sci. J., 15: 139-150.
- Khanna, P., S.C. Jain, A. Panagariya and V.P. Dixit, 1981. Hypoglycemic activity of polypeptide-p from a plant source. J. Nat. Prod., 44(6): 648-655.
CrossRef PMid:7334382
- Liu, R., J.Z. Zhang, Y.N. Zheng, B. Xu and W.C. Liu, 2012. Screening pancreatic lipase inhibitors from fruits and vegetables. J. Jilin Agric. Univ., 34(2): 211-215.
-
Mansi, K., A.M. Abushoffa, A. Disi and T. Aburjai, 2009. Hypolipidemic effects of seed extract of celery (Apium graveolens) in rats. Pharmacogn. Mag., 5(20): 301-305.
CrossRef
- McDougall, G.J., N.N. Kulkarni and D. Stewart, 2009. Berry polyphenols inhibit pancreatic lipase activity in vitro. Food Chem., 115(1): 193-199.
CrossRef
- Micic, D., T. Ivkovic-Lazar, R. Dragojevic, J. Jorga, E. Stokic and et al., 1999. Orlistat, a gastrointestinal lipase inhibitor, in therapy of obesity with concomitant hyperlipidemia. Med. Pregl., 52(9-10): 323-333.
PMid:10624380
- Minister of Health, Ministry of Science and Technology and National Bureau of Statistics, 2002. The Nutrition and Health Status of the Chinese People 2002.
- Platel, K. and K. Srinivasan, 2000. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung, 44(1): 42-46.
CrossRef
- Platel, K. and K. Srinivasan, 2003. Digestive stimulant action of spices: A myth or reality? Ind. J. Med. Res., 119(5): 42-46.
-
Ramakrishna, R.R., K. Platel and K. Srinivasan, 2003. In vitro influence of spices and spice-active principles on digestive enzymes of rat pancreas and small intestine. Nahrung, 47(6): 408-412.
CrossRef PMid:14727769
-
Taniguchi, K., C. Ishii, M. Sasago, Y. Kiire and Y. Yamazaki, 1985. Studies of lipase inhibitors present in natural materials 1: Screening test and some properties of crude lipase inhibitor extracted from garden radish seed, Raphanus sativus L. Bull. Faculty Agric. Meiji Univ., 69: 15-28.
- Tsujita, T. and H. Okuda, 1983. Carboxylestrase in rat and human sera and their relationship to serum acylamidases and cholinesterase. Eur. J. Biochem., 133: 215-220.
CrossRef PMid:6852027
- Wang, W., K. Wang and T. Li, 2001. A study on the epidemiological characteristics of obesity in Chinese adults. Zhonghua Liuxingbingxue Zazhi, 22(2): 129-132.
PMid:11860863
-
WHO (World Health Organization), 2011. Obesity and Overweight. Retrieved from: http://www. who.int/ mediacentre/factsheets/ fs311/en/ index.htmL. (Accessed on: September 26, 2011).
Direct Link
- Xu, B.J., S.H. Yuan and S.K. Chang, 2007. Comparative studies on the antioxidant activities of nine common food legumes against copper-induced human low-density lipoprotein oxidation in vitro. J. Food Sci., 72(7): 522-527.
CrossRef PMid:17995667
- Xu, B.J., L.K. Han, Y.N. Zheng, J.H. Lee and C.K. Sung, 2005. In vitro inhibitory effect of triterpenoidal saponins from Platycodi radix on pancreatic lipase. Arch. Pharm. Res., 28(2): 180-185.
CrossRef PMid:15789748
-
Yu, L.M., M.M. Zhao, B. Yang, Q.Z. Zhao and Y.M. Jiang, 2007. Phenolics from hull of Garcinia mangostana fruit and their antioxidant activities. Food Chem., 104(1): 176-181.
CrossRef
- Zapf, J., E. Schoenle, M. Waldvoge, M. Sand and E.R. Foresch, 1981. Effects of trypsin treatment of rat adipocyte on biological effects and binding of insulin and insulin-like growth factors: Further evidence for the action of insulin-like growth factors through the insulin receptor. Eur. J. Biochem., 133: 605-609.
CrossRef
- Zhang, Z.S., L. Zhao, H. Mu and M.R. Suo, 2009. Study on extraction and purification of the flavonoids from Garcinia mangostana L. pericarp. Food Res. Dev., 30(6): 11-15.
- Zhao, Y. and P.Y. Li, 2007. Studies on the chemical constituents of the pericarps of Garcinia Mangostana L. and its pharmacological activities. Ph.D. Thesis, Retrieved from: http://dlib.cnki. net/ kns50/detail.aspx?filename=2008126940.nh&dbname=CDFD2008.
Direct Link
- Zheng, C.D., Y.Q. Duan, J.M. Gao and Z.G. Ruan, 2010. Screening for anti-lipase properties of 37 traditional Chinese medicinal herbs. J. Chinese Med. Assoc., 73(6): 319-324.
CrossRef
-
Zhou, H.C., Y.M. Lin, S.D. Wei and F.Y. Tam, 2011. Structural diversity and antioxidant activity of condensed tannins fractionated from mangosteen pericarp. Food Chem., 129(4): 1710-1720.
CrossRef
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
|
|
![](http://www.maxwellsci.com/images/AJFST-maxw.jpg) |
ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
![Submit Manuscript](../images/sub.jpg) |
Information |
|
|
|
Sales & Services |
|
|
|