Abstract

Compound Sulfadiazine suspension is used mainly to prevent and cure E. coli, Salmonella infection of chicken in veterinary clinical application. Effect of compound Sulfadiazine suspension on growth performance of broiler in clinical efficacy trial was studied in the study. One hundred eighty 15-day-old broilers were divided randomly into six groups, blank control group, negative control group, Trisulmixos gavage group, Trisulmixos drinking group, Sufuning gavage group and Sufuning drinking group, respectively. There were three repeating treatments in each group and ten broilers in each treatment. Results showed that compound Sulfadiazine suspension can promote the feed conversion rate of broiler when curing E. coli, Salmonella infection of chicken. Both from the perspective of efficacy and from the perspective of growth performance, giving drug by gavage were more effective than giving by drinking. When two products of Compound Sulfadiazine suspension were compared, the indicators of Sufuning were a little better Trisulmixos.

Keywords:

Broiler, Escherichia coli, salmonella, sufuning, trimethoprim, trisulmixos,

References

1. Agunos, A., D. Leger and C. Carson, 2012. Review of antimicrobial therapy of selected bacterial diseases in broiler chickens in Canada. Can. Vet. J., 53(12): 1289-1300.
   PMid:23729827 PMCid:PMC3500121    
2. Ajay, K. and P. Kaushik, 2011. Antibacterial activity of Christella dentata frosk. Study in different seasons. J. Chem. Pharmaceut. Res., 3(6): 153-158.
   
3. Ali, F.H. and D.A. Zahran, 2010. Effect of growth enhancers on quality of chicken meat during cold storage. Adv. J. Food Sci. Technol., 2(4): 219-226.
   
4. Chaudhari, A.A. and J.H. Lee, 2013. Evaluation of the adjuvant effect of Salmonella-based Escherichia coli heat-labile toxin B subunits on the efficacy of a live Salmonella-delivered avian pathogenic Escherichia coli vaccine. Avian Pathol., 42(4): 365-372.
   CrossRef    PMid:23815619    
5. Chretin, J.D., K.M. Rassnick, N.A. Shaw, K.A. Hahn, G.K. Ogilvie, O. Kristal, N.C. Northrup and A.S. Moore, 2007. Prophylactic trimethoprim-sulfadiazine during chemotherapy in dogs with lymphoma and osteosarcoma: A double-blind, placebo-controlled study. J. Vet. Intern. Med., 21(1): 141-148.
   CrossRef    PMid:17338162     
6. Ghosh, T.K., S. Haldar, M.R. Bedford, N. Muthusami and I. Samanta, 2012. Assessment of yeast cell wall as replacements for antibiotic growth promoters in broiler diets: Effects on performance, intestinal histo-morphology and humoral immune responses. J. Anim. Physiol. An. N., 96(2): 275-284.
   CrossRef    PMid:21535233    
7. Giombelli, As., R. Cavani and M.B. Gloria, 2013. Evaluation of three sampling methods for the microbiological analysis of broiler carcasses after immersion chilling. J. Food Protect., 76(8): 1330-1335.
   CrossRef    PMid:23905787    
8. Kongsaengdao, S., K. Samintarapanya, K. Oranratnachai, W. Prapakarn and C. Apichartpiyakul, 2008. Randomized controlled trial of pyrimethamine plus sulfadiazine versus trimethoprim plus sulfamethoxazole for treatment of toxoplasmic encephalitis in AIDS patients. J. Int. Ass. Phys. AIDS Care, 7(1): 11-16.
   CrossRef    
9. Mathlouthi, N., T. Bouzaienne, I. Oueslati, F. Recoquillay, M. Hamdi, M. Urdaci and R. Bergaoui, 2012. Use of rosemary, oregano and a commercial blend of essential oils in broiler chickens: In vitro antimicrobial activities and effects on growth performance. J. Anim. Sci., 90(3): 813-823.
   CrossRef    PMid:22064737    
10. Salim, H.M., H.K. Kang, N. Akter, D.W. Kim, J.H. Kim, M.J. Kim, J.C. Na, H.B. Jong, H.C. Choi, O.S. Suh and W.K. Kim, 2013. Supplementation of direct-fed microbials as an alternative to antibiotic on growth performance, immune response, cecal microbial population and ileal morphology of broiler chickens. Poultry Sci., 92(8): 2084-2090.
    CrossRef    PMid:23873556    
11. Skjot-Rasmussen, L., L. Jakobsen, S.S. Olsen, N. Frimodt-Møller and A.M. Hammerum, 2013. Unusual pathogenic B1 genotype (yjaA/TspE4.C2) detected among Escherichia coli from pig, chicken broiler meat and human extraintestinal infection. J. Med. Microbiol., 62: 1259-1262.
    CrossRef    PMid:23699062    
12. Zhihui, H., X. Xilong, M. Qiu, J. Wang, M. Zou and Z. Chen, 2009. Antibacterial activies and efficacy of taurolidine against experimentally induced mixed infection in chickens. Chinese Agric. Sci. Bull., 25(11): 7-11.
    

Competing interests

The authors have no competing interests.

Open Access Policy

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Copyright

The authors have no competing interests.