Research Article | OPEN ACCESS
Assessment of Hypolipidaemic Effect of Leptadenia Hastata Leaves in Albino Rats
1Muhammad Yalwa Gwarzo and 2Zubaida Said Ameen
1Department of Medical Laboratory Science, Faculty of Medicine
2Department of Biochemistry, Bayero University Kano, PMB 3011, Kano, Nigeria
Advance Journal of Food Science and Technology 2015 1:1-6
Received: July 12, 2013 | Accepted: August 24, 2013 | Published: January 05, 2015
Abstract
This study was designed to determine the effect of Leptadenia hastata leaves on serum lipid profile and glucose in experimentally-induced hyperlipidemic Wistar rats. Sixteen adult Wistar rats were randomly assigned into four groups of four rats each. Group 1 was the hyperlipidemic group (positive control), Group 2 was the hyperlipidemic supplemented with L. hastata leaves group, Group 3 was the normolipidemic supplemented with L. hastata leaves group and Group 4 normal group fed on normal diet (negative control). The changes in the serum lipid profile and glucose were monitored after three weeks. The result of the serum lipid analysis showed a significant (p<0.05) reduction in the serum total cholesterol, low-density lipoprotein cholesterol with concurrent significant (p<0.05) increase in serum high density lipoprotein cholesterol in hyperlipidemic group treated with L. hastata leaves (group 2) compared with the hyperlipidemic group (group 1). Serum glucose level was also significantly higher in hyperlipidemic group (p<0.05) compared with other three groups. The result of this study suggests possible hypolipidemic effect of L. hastata leaves.
Keywords:
Hyperlipidemia, Leptadenia hastata, lipoproteins,
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The authors have no competing interests.
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