Research Article | OPEN ACCESS
Liver Enzymes and its Correlates in Treated and Newly Diagnosed Type 2 Diabetes Mellitus Patients in Osogbo, South West, Nigeria
1, 2A.O. Odewabi, 3E.G. Akinola, 2O.A. Ogundahunsi, 2V.A. Oyegunle, 2A.A. Amballi, 4T.H. Raimi and 5F.A. Adeniyi
1Department of Chemical Pathology, Olabisi Onabanjo University Teaching Hospital
2Department of Chemical Pathology, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria
3Department of Chemical Pathology, State Hospital, Osogbo, Osun State, Nigeria
4Department of Medicine, Ekiti State University/University Teaching Hospital,
Ado-Ekiti, Ekiti State, Nigeria
5Department of Chemical Pathology, College of Medicine, University of Ibadan,
Ibadan, Oyo State, Nigeria
Asian Journal of Medical Sciences 2013 5:108-112
Received: July 17, 2013 | Accepted: August 16, 2013 | Published: October 25, 2013
Abstract
Previous studies suggested that alteration in liver enzymes may be a predisposing and probable risk factor of Type 2 Diabetes Mellitus (T2DM) and complication of long standing T2DM. The aim of this study was to evaluate the prevalence of elevated liver enzymes in T2DM on treatment and the newly diagnosed in a Nigerian population and the relationship between the duration of the T2DM and the levels of the enzymes. A total of 117 subjects comprising 52 and 25 T2DM on treatment and newly diagnosed respectively; and 40 controls were recruited. Ten milliliter of blood were collected from antecubital vein of the subjects for analysis. There was no significant difference in the level of gamma-glutamyl transferase (GGT) in both T2DM patients, whereas there were significant elevations (p<0.05) of alanine amino transferase (ALT) and alkaline phosphatase (ALP) in newly diagnosed and ALT (p<0.001) and ALP (p<0.01) in patients on treatment when compared with the control. There were significant (p<0.001) differences in the levels of fasting plasma glucose (FPG) in both T2DM patients compared with the control. Prevalence of elevated ALT was 30.77%, ALP was 55.76% and GGT was 0% in patients on treatment; ALT was 32.0%, ALP was 56.0% and GGT was 4.0% in newly diagnosed patients compared with ALT of 0%, ALP of 30% and GGT of 0% in the control subjects. A positive correlation between ALT (r = 0.265, p<0.05), FPG (r = 0.474, p<0.01) and T2DM duration and between FPG and ALT (r = 0.311, p<0.01) and ALT and ALP (r = 0.234, p<0.05) were observed in diabetic patients. Overall T2DM in both categories of patients predisposes to elevated levels of ALT and ALP but only ALT may be a useful biomarker for monitoring hepatic complication in T2DM without underlying hepatitis.
Keywords:
Diabetes, duration, liver enzymes, prevalence,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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