Research Article | OPEN ACCESS
Assessment of Some Selected Trace Metals in Chronic Myeloid Leukemia Patients in a Tertiary Health Facility in South West Nigeria
1E.O. Akanni, 2A.J. Onuegbu, 3T.O. Adebayo, 4B.A. Eegunranti and 5T.Oduola
1Department of Biomedical Science, Ladoke Akintola University of
Technology, P.M.B. 4400, Osogbo. Nigeria
2Department of Chemical Pathology, College of Health Sciences, Nnamdi Azikiwe
University, Nigeria
3Department of Chemical Pathology
4Department of Psychiatry, College of Health Sciences, Ladoke Akintola University of
Technology, P.M.B. 4400, Osogbo, Nigeria
5Department of hematology and Blood Transfusion, Obafemi Awolowo University
Teaching Hospital, Ile-Ife, Nigeria
Asian Journal of Medical Sciences 2013 4:71-75
Received: May 01, 2013 | Accepted: June 03, 2013 | Published: August 25, 2013
Abstract
Some selected trace metals; Iron (Fe), Copper (Cu), Manganese (Mn), Chromium (Cr), Selenium (Se), Calcium (Ca), Zinc (Zn) and Magnesium (Mg) in Chronic Myeloid Leukemia (CML) patients were assessed. Seventy five (75) leukemic patients and 50 apparently healthy control subjects were evaluated in this study. Hematological parameters were estimated by automation SYSMEX KX-21N and the trace elements analysed using Atomic Absorption Spectrophotometry. There were statistical significant differences between serum Fe, Cu, Mn, Se, Ca, Zn and Mg of leukemic patients and that of their respective control subjects (p<0.05) while there was no significant difference between serum chromium of leukemic patients and the control subjects (p>0.05). Variation also existed between the patients and control values in the hematological parameters such as: PCV, MCV, MCHC, WBC, platelet etc. The study reveals that serum trace elements are useful indices of the extent of the disease in leukemia patients, their levels are independent of a non specific acute-phase reaction, restoration of serum trace elements are useful in assessing response to treatment in leukemia patients. Monitoring of the respective trace elements in the CML patients could therefore be an essential part of managing the patients.
Keywords:
Chronic myeloid leukemia, hematological parameters, trace metals,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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