Abstract

Enteric fever has been implicated in complications such as severe sepsis and in alteration of some biochemical and hematological parameters. Enteric fever affects the intestine, which is also the site for lipid absorption, but its possible effect on lipid metabolism is unclear. The present study was aimed at estimating the lipid profile of enteric fever patients in Enugu metropolis. Lipid profile of 200 enteric fever patients and 100 apparently healthy subjects in Enugu metropolis were determined using standard techniques. Enteric fever was investigated using rapid slide titration method and the confirmatory test done with Enterocheck-WB® kit. Serum Total Cholesterol (TC), Triacylglycerol (TG), High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C) and Very Low Density Lipoprotein Cholesterol (VLDL-C) were assayed using standard operative procedures. Statistical analysis was done with graph pad prism computer soft ware using student’s t-test to test for statistical significance. P-values of <0.05 were considered to be statistically significant. The lipid profile of all the patients showed non-significant difference (p>0.05) when compared with the control. However, when the male and female subjects where separately analyzed, TC and LDL-C significantly increased (p<0.05) in the male subjects compared to the male controls, whereas the female subjects showed significant decrease (p<0.05) compared to the female control. The study suggests that lipid profile is not significantly altered in enteric fever infection and thus may be useless in enteric fever management.

Keywords:

Apoproteins, hyperlipidemia, total cholesterol, typhoid infection,

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