Research Article | OPEN ACCESS
Anti-ulcerogenic and Anti-inflammatory Activity of Cissus multistriata Extract in Experimental Animals
Omale James, Eleojo Berikisu Ojogbane, Okpachi Christopher Abbah and Moses Oluwatobi Tehinse
Department of Biochemistry, Faculty of Natural Sciences, Kogi State
University, P.M.B. 1008 Anyigba, Kogi State, Nigeria
British Journal of Pharmacology and Toxicology 2013 3:74-79
Received: November 19, 2012 | Accepted: January 11, 2013 | Published: June 25, 2013
Abstract
This present study was undertaken to evaluate the anti-ulcerogenic and anti-inflammatory properties of methanol extract from the leaves of Cissus multistriata. Gastric ulcer and inflammation were induced in experimental animals using ethanol and acetic acid respectively. Anti-ulcerogenic action of C. multistriata was evaluated in albino rats at doses of 30, 50 and 100 mg/kg body weight. Cissus multistriata showed gastro-protective action in the groups and the protection was dose dependent and comparable to the standard drug (Omeprazole) used. The mechanism involved in the gastro- protective effect of C. multistriata may be related to the mucosal protector factors, such as Nitric Oxide (NO) and Sulfhydryl (SH) compounds. Anti-inflammatory activity was also studied on the plant using the paw edema method on different groups of rats. The methanol extract of C. multistriata exhibited potent anti-inflammatory activity at 150 mg/kg b.w at 4 h after administration to group 4 when compared with reference standard drug (Indomethacin). Group 2 had 72% inhibition of edema as compared to 55% inhibition offered by the extract at 150 mg/kg, thus showing a great effect at higher doses. From this study, it is clear that C. multistriata leaf extract had significant anti-ulcer activity in animal model. It also demonstrated high anti-inflammatory potential at 150 mg/kg b.w. These observed pharmacological activities therefore, provide scientific support for the ethno-medicinal uses of this plant.
Keywords:
Anti-inflammatory, anti-ulcerogenic, Cissus multistriata, experimental animals,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
|
|
![](http://www.maxwellsci.com/images/BJPT-maxw.jpg) |
ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
![Submit Manuscript](../images/sub.jpg) |
Information |
|
|
|
Sales & Services |
|
|
|