Abstract

This present study was undertaken to evaluate the anti-ulcerogenic and anti-inflammatory properties of methanol extract from the leaves of Cissus multistriata. Gastric ulcer and inflammation were induced in experimental animals using ethanol and acetic acid respectively. Anti-ulcerogenic action of C. multistriata was evaluated in albino rats at doses of 30, 50 and 100 mg/kg body weight. Cissus multistriata showed gastro-protective action in the groups and the protection was dose dependent and comparable to the standard drug (Omeprazole) used. The mechanism involved in the gastro- protective effect of C. multistriata may be related to the mucosal protector factors, such as Nitric Oxide (NO) and Sulfhydryl (SH) compounds. Anti-inflammatory activity was also studied on the plant using the paw edema method on different groups of rats. The methanol extract of C. multistriata exhibited potent anti-inflammatory activity at 150 mg/kg b.w at 4 h after administration to group 4 when compared with reference standard drug (Indomethacin). Group 2 had 72% inhibition of edema as compared to 55% inhibition offered by the extract at 150 mg/kg, thus showing a great effect at higher doses. From this study, it is clear that C. multistriata leaf extract had significant anti-ulcer activity in animal model. It also demonstrated high anti-inflammatory potential at 150 mg/kg b.w. These observed pharmacological activities therefore, provide scientific support for the ethno-medicinal uses of this plant.

Keywords:

Anti-inflammatory, anti-ulcerogenic, Cissus multistriata, experimental animals,

References

Competing interests

The authors have no competing interests.

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The authors have no competing interests.