Research Article | OPEN ACCESS
Lactogenic and Cytogenetic Effects of Ochratoxin A in Adult Male Rats and Pups
Duraid A. Abbas
Collage of Veterinary Medicine, Baghdad University, Iraq
British Journal of Pharmacology and Toxicology 2013 3:101-105
Received: January 09, 2013 | Accepted: January 31, 2013 | Published: June 25, 2013
Abstract
Lactogenic and cytogenic effects were studied for Ochratoxin (OTA) dosed daily orally throughout lactation period to four groups each consist of newly parturated female rats at doses (0, 60, 120, 180) &mug/Kg. BW representing control, T1, T2, T3 group. Micronucleus test results indicated significant increase in number of fragmented and budding nuclei of T1, T2, T3 adult rat bone marrow in dose dependent manner in comparison with control group. The lactating results show no significant change in weekly pup group’s weight gain or length throughout lactating period. Alough there were no changes recorded in viability index of all pups groups, lactating index recorded considerable decline in T1, T2, T3 pups groups according with their adult OTA doses with maximum pups death at the third lactating week. Different histopathological lesions observed in pups liver, kidney and spleen that increase in severity proportionally with their OTA mother doses.
Keywords:
Cytogenetic, lactogenic, OTA, rats and pups,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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