Abstract

Aqueous leaves extract of Moringa oleifera Lam. was studied for its anti-hyperglycemic properties in normal and mildly diabetic mice by the Oral Glucose Tolerance Test (OGTT). The glibenclamide (1 mg/100 g BW) was used as reference drug. And mildly diabetes was induced by a single intraperitoneal injection of sterptozotocin (6 mg/100 g BW). The blood glucose tolerance efficiency of the extract at doses of 100, 200 and 300 mg/100 g BW in normal group were 25.99, 31.25 and 43.19% and in mildly diabetic mice were 45.17, 53.31 and 59.16% of glibenclamide, respectively. In conclusion, the aqueous leaves extract of Moringa oleifera Lam. revealed anti-hyperglecemic activity in normal mice and improved the glucose tolerance impairment in mildly diabetic mice. Thus, Moringa oleifera Lam may be introduced as an anti-diabetic herb.

Keywords:

Diabetes, glibenclamide, glucose tolerance, Moringa oleifera Lam, OGTT, stretozotocin,

References

Competing interests

The authors have no competing interests.

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