Research Article | OPEN ACCESS
Anti-hyperglycemic Properties of Moringa oleifera Lam. Aqueous Leaf Extract in Normal and Mildly Diabetic Mice
1, 2Ampa Luangpiom, 2Watchara Kourjampa and 2Tanaree Junaimaung
1Applied Taxonomic Research Center, Khon Kaen University, Khon Kaen, Thailand
2Department of Biology, Faculty of Science, Khon Kaen University, Thailand
British Journal of Pharmacology and Toxicology 2013 3:106-109
Received: January 12, 2013 | Accepted: February 07, 2013 | Published: June 25, 2013
Abstract
Aqueous leaves extract of Moringa oleifera Lam. was studied for its anti-hyperglycemic properties in normal and mildly diabetic mice by the Oral Glucose Tolerance Test (OGTT). The glibenclamide (1 mg/100 g BW) was used as reference drug. And mildly diabetes was induced by a single intraperitoneal injection of sterptozotocin (6 mg/100 g BW). The blood glucose tolerance efficiency of the extract at doses of 100, 200 and 300 mg/100 g BW in normal group were 25.99, 31.25 and 43.19% and in mildly diabetic mice were 45.17, 53.31 and 59.16% of glibenclamide, respectively. In conclusion, the aqueous leaves extract of Moringa oleifera Lam. revealed anti-hyperglecemic activity in normal mice and improved the glucose tolerance impairment in mildly diabetic mice. Thus, Moringa oleifera Lam may be introduced as an anti-diabetic herb.
Keywords:
Diabetes, glibenclamide, glucose tolerance, Moringa oleifera Lam, OGTT, stretozotocin,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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