Research Article | OPEN ACCESS
In Vivo Antimicrobial Activity of Ethanol Extract of Sumac (Rhus coriaria) on Klebsiella pneumonia
Sarween Omar Taha
Department of Biology, Faculty of Science, University of Soran, Erbil, Iraq
British Journal of Pharmacology and Toxicology 2013 1:1-4
Received: October 12, 2012 | Accepted: December 17, 2012 | Published: February 25, 2013
Abstract
Eight isolates of Klebsiella pneumonia were obtained from different human specimens, identified through cultural, morphological and biochemical examination, in addition to API20E system. Susceptibility test to six antimicrobials were performed for all isolates. The isolates were grouped to four antibiogram, according to their resistance to tested antimicrobials; all isolates were resist to Ampicillin and Amikacin, or resist to at least one more antibiotics. The Minimum Inhibition Concentration (MIC) of ethanol extract for Rhus coriaria was determined (700 μg/mL). Sub-MIC was used as curing agents. Treating Mus Musculus mice (WBC count of 4.5×103) with Sub-MIC of R. coriaria extract, after nosily infected with more resistant isolate K. pneumoniae K4 and appearance of disease septum with 11.3×103 WBC count (after 5 days from infection). After treating the infected mice with plant extract and after 16 days from infection, the WBC count reduced to 5.1×103 μL which is in the normal range and the mice were healthy with good physiological behavior. While the infected mice and untreated with plant extract the WBC and other immunological parameters remain high even after 16 days from infection.
Keywords:
Antimicrobial, ethanolic extract, Klebsiella pneumonia, Rhus coriaria,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
|
|
![](http://www.maxwellsci.com/images/BJPT-maxw.jpg) |
ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
![Submit Manuscript](../images/sub.jpg) |
Information |
|
|
|
Sales & Services |
|
|
|