Research Article | OPEN ACCESS
Effects of Aqueous Extract of Cyphostemma glaucophilla Leaves on Some Specific and Non-specific Immune Responses in Albino Rats
1Ojogbane Eleojo, 1Omale James and 2Nwodo Okwesili Fred Chiletugo
1Department of Biochemistry, Kogi State University, Anyigba, Nigeria
2Department of Biochemistry, University of Nigeria Nsukka, Nigeria
British Journal of Pharmacology and Toxicology 2013 4:142-146
Received: November 19, 2012 | Accepted: January 11, 2013 | Published: August 25, 2013
Abstract
Cyphostemma glaucophilla is used in the management of kwashiorkor, because impaired immune responses is associated with malnourishment the modulatory activity of aqueous leaves extract of Cyphostemma glaucophilla on primary and secondary humuoral responses, in vivo leucocyte mobilization, Delayed Type Hypersensitive Reaction (DTHR), haemoglobin, packed cell volume and white blood cell count were evaluated. The extract at 250 and 500 mg/kg stimulated significant (p<0.05) dose dependent increase in primary and secondary sheep red blood cell specific antibody titre comparable to Levamisol. Extract at doses of 100 and 250 mg/kg induced leucocyte mobilization while 500 mg/kg inhibited leucocyte mobilization. The extract at 250 and 500 mg/kg produced significant (p<0.05) inhibition of DTHR in rats by 20.24 and 67.77%, respectively. The extract also induced significant (p<0.05) increases in packed cell volume by 3.0% at the lowest dose of 0.5 mg/kg and 11.2% at the highest dose of 2.0 mg/kg. However, the extract was insensitive to haemoglobin and total white blood cell count. Result has established cellular and humoral immunomodulatory activities of Cyphostemma glaucophilla aqueous leaves extract.
Keywords:
Cyphostemma glaucophilla, humoral response, hypersensitivity, immunomodulatory, leucocyte mobilization,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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