Research Article | OPEN ACCESS
Effect of Soybean Oil Supplemented Diet on Fatty Acid Level and Lipid Profile of Albino Rats
1Friday O. Uhegbu, 1Amadike E. Ugbogu, 1Kingsley C. Nwoku and 2Victor C. Ude
1Department of Biochemistry, Abia State University, PMB 2000, Uturu-Nigeria
2Department of Medical Biochemistry, College of Medicine, Enugu State University of Science and Technology, PMB 01660, Enugu, Nigeria
British Journal of Pharmacology and Toxicology 2013 4:158-162
Received: March 07, 2013 | Accepted: April 22, 2013 | Published: August 25, 2013
Abstract
This aim of this study is to evaluate the effect of soybean oil supplemented diet on the fatty acid level and lipid profile of male albino rats. Forty healthy male albino rats weighing between 96-110 g and aged 6 weeks were used. The rats were placed randomly into four groups of ten animals each. Group 1 served as control and had no soybean oil in their feed. Group 2-4 was placed on soybean oil supplemented diet 10, 20 and 30% respectively. The experiment lasted for 14 days. The results showed that the animals had significant (p<0.05) increase in body weight compared with the control. Triacylglycerol, phospholipid and total cholesterol level were also significantly (p<0.05) decreased, 80.46±3.76 to 78.46±3.22; 15.36±0.34 to 10.12±0.75; and 116.65±6.38 to 110.95±6.36 mg/dL respectively. Very Low Density Lipoprotein (VLDL) and Low Density Lipoprotein (LDL) were also significantly decreased, 15.56±2.56 to 13.45±2.76; 68.88±2.54 to 56.59±2.14 mg/dL respectively. However High Density Lipoprotein (HDL) showed significant (p<0.05) increase 60.37±1.36 to 65.75±1.89 mg/dL. Cholesterol, triacylglycerol and fatty acids are significant and independent risk factors of adverse cardiovascular events. The clinical and nutritional implication of these results is discussed.
Keywords:
Arthrosclerosis, cardiovascular disease, cholesterol, lipogenesis, osteoarthritis,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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