Research Article | OPEN ACCESS
Effects of Acrylamide Toxicity on Growth Performance and Serobiochemisty of Wistar Rats
1Almoeiz Y. Hammad, 2Maha E. Osman and 3Warda S. Abdelgadir
1Faculty of Pharmacy, Sudan International University, P.O. Box 12769, Khartoum, Sudan
2Commission for Biotechnology and Genetic Engineering, National Centre for Research, Ministry of Science and Communication, P.O. Box 2404, Khartoum, Sudan
3Food Research Centre, Ministry of Science and Communication, P.O. Box 213, Khartoum, Sudan
British Journal of Pharmacology and Toxicology 2013 4:163-168
Received: March 21, 2013 | Accepted: April 08, 2013 | Published: August 25, 2013
Abstract
The present study was conducted to obtain information on the effects of various dietary doses of the Acrylamide on Wistar rats. Emphasis was put on changes on growth and serobiochemical constituents of treated rats. Extra pure Acrylamide was fed to Wistar rats at 10, 30, 60 and 90 mg/kg, respectively of the standard diet for 6 weeks. Acrylamide was then withdrawn from the diet for four weeks. Incorporation in diet of the doses 10, 30, 60 and 90 mg/kg acrylamide was toxic to Wistar rats, but fatal only to those of group 5 fed on 90 mg/kg, where five rats (62.5%) died on day 18 of the experimental period. Depression in growth was observed in rats that had been fed on the experimental doses for 6 weeks. Neurotoxicity was observed only in the rats fed on acrylamide at 10 (Group 2) and 60 mg/kg (Group 4). These findings were accompanied by alterations in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities and albumin, globulin and cholesterol concentrations. The alteration on enzymes activities, urea and cholesterol remained even after the 4 weeks withdrawal of acrylamide, whereas, total protein, albumin, globulins and electrolytes concentration returned to their normal values. Acrylamide is considered neurotoxic at dietary levels of 10 and 60 mg/kg and enterohepatonephrotoxic to Wistar rats at dietary level of 10, 30, 60 and 90 mg/kg and fatal at the treatment dose of 90 mg/kg.
Keywords:
Acrylamide, body weight, electrolyte, metabolites, neurotoxicity, serum enzymes,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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