Research Article | OPEN ACCESS
Studies on the Analgesic and Anti-inflammatory Properties of Hydro-alcohol Extract of Caralluma dalzielii N.E.Br (Asclepiadaceae) in Rats and Mice
1A.H. Umar, 1M. Mabrouk, 2N.M. Danjuma and 2A. Yaro
1Department of Human Physiology, ABU Zaria, Nigeria
2Department of Pharmacology and Therapeutics, ABU Zaria, Nigeria
British Journal of Pharmacology and Toxicology 2013 5:169-175
Received: March, 14, 2012 | Accepted: May 10, 2012 | Published: October 25, 2013
Abstract
The analgesic and anti-inflammatory potentials of the hydro-alcohol extract of Caralluma dalzielii N.E.Br, a Nigerian traditional medicinal plant was studied using thermal and chemical-induced pain models and carrageenan-induced acute inflammation. The acute toxicity and the phytochemical constituents of the extract were also determined. The results showed that the extract at a dose of 80 mg/kg significantly (p<0.05) prolonged the pain reaction times in the hot-plate pain model at 30 and 60 min and reduced acetic acid-induced writhing in mice and decrease pain score in formalin induced pain in rats at all doses tested. The hydro-alcohol extract of Caralluma dalzielii N.E.Br demonstrated significant (p<0.05) anti-inflammatory activity against acute inflammation induced by carrageenan. The estimated LD50 of the extract was found to be 288.53 mg/kg. Phytochemical analysis revealed the presence of tannins, saponins, anthraquinones, glycosides and flavonoids. These findings indicate that the hydro-alcohol extract of Caralluma dalzielii has analgesic and anti-inflammatory properties and could be beneficial in alleviating painful inflammatory conditions.
Keywords:
Acetic acid-induced abdominal constriction, analgesic, anti-inflammatory, Caralluma dalzielii,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
|
|
![](http://www.maxwellsci.com/images/BJPT-maxw.jpg) |
ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
![Submit Manuscript](../images/sub.jpg) |
Information |
|
|
|
Sales & Services |
|
|
|