Research Article | OPEN ACCESS
Effect of Light and Storage Time on Vitamin E in Pharmaceutical Products
Pham Phuoc Nhan and Nguyen Kim Hoa
Department of Biochemistry and Plant Physiology, College of Agriculture and Applied Biology,
Cantho University, 3-2 Street, Cantho City, Vietnam
British Journal of Pharmacology and Toxicology 2013 5:176-180
Received: June 11, 2012 | Accepted: June 25, 2013 | Published: October 25, 2013
Abstract
Vitamin E is an important oxidant for both plant and animal and a lipid soluble vitamin which occurs naturally in edible plant oils and able to be synthesized by oxygenic bacteria. Besides, cooking oils and edible oil containing seeds, human can intake vitamin E via pharmaceutical products. With simply spectral method, vitamin E contents in tablets were quantified easily during storage. Vitamin E levels in medical products sold on Vietnamese market varied among producers ranging from 15 mg up to about 360 mg/tablet. Vitamin E in eight selected products was degraded gradually with prolonged storage time but much more rapidly in scatter light exposure condition than in the dark. The more vitamin E in the tablets, the quicker degradation occurred. Tablets exposed to natural sun light or UV source depleted vitamin E significantly within 5 h, approximately 50% for both lighted conditions. There was a relatively high tight correlation $(R^2 = 0.8266)$ between tablet price and its vitamin E content. Customer should buy the higher price products rather than the cheaper ones to get sufficient amount of vitamin E. Pharmaceutical vitamin E products should be used up soon after being bought or kept away any light sources.
Keywords:
α-tocopherol, dark, tablet, UV light,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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