Research Article | OPEN ACCESS
Reproductive Toxicity of Orthosiphon stamineus Benth (Java tea) in Swiss Albino Mice
Abdulaziz A. Al-Yahya
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University,
P.O. Box 2457, Riyadh-11451, Saudi Arabia, Tel.: 00966-505468783; Fax: 00966-14677200
British Journal of Pharmacology and Toxicology 2013 5:181-187
Received: June 21, 2013 | Accepted: July 05, 2013 | Published: October 25, 2013
Abstract
The java tea is significantly used in traditional medicine for its anti-allergic, antihypertensive, anti-inflammatory and diuretic properties. The present study is designed to assess the effect of java tea after its chronic use on male reproduction, cytological and biochemical changes in Swiss albino mice. Java tea was administered orally at the doses 62.50, 125 and 250 mg/kg/day for 90 days. Higher dose of Java tea caused a significantly reduction in sperm count and motility along with an induction of morphological abnormalities in spermatozoa and also induced aberrations in sperm chromosomes compare to normal mice. Higher dose caused a significant increase in plasma levels of estradiol and decrease in testosterone levels. It also reduced the fertility index in male and female mice and that indicates towards the induction of dominant lethal mutations after sub-chronic administration of Java tea particularly in higher dose treated group. Malondialdehyde (MDA) level was found to be increased along with a concomitant reduction in Non-Protein Sulfhydryl (NP-SH) in testes tissue. In conclusion, Java tea administration at higher dose induces reproductive toxicity in mice and the study paves a path to further investigate its clinical effects on reproductive system.
Keywords:
Fertility, java tea, oxidative stress, pituitary gonadal hormones, reproductive toxicity, sperm count,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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