Research Article | OPEN ACCESS
Determination of Phytochemical Constituents of the Aqueous Extracts of the Leaves, Stem Bark and Root Bark of Vitex doniana and its Effects on Lipid Profile of Albino Rats
1D.B. James, 1O.A. Kadejo, 1C. Nwochiri and 2C.D. Luca
1Department of Biochemistry, Ahmadu Bello University, Samaru Zaria, Nigeria
2Department of Biochemistry, University of Jos, Nigeria
British Journal of Pharmacology and Toxicology 2013 6:210-214
Received: November 08, 2012 | Accepted: December 22, 2012 | Published: December 25, 2013
Abstract
The phytotochemical screening of Leaves, stem bark and root bark of Vitex doniana were carried out and some Lipid profile were assessed in normal albino rats after administration of the extracts. Twenty mixed sex Wistar rats weighing 150-200 g was divided into 4 groups. Group 1 serves as control while 2, 3, 4 were administered (100 mg/kg) aqueous extracts of leaves, stem bark and root bark of Vitex doniana. The phytochemical screening of the leaves, stem bark and root bark of Vitex doniana shows the presence of Glycosides, Cardiac glycosides, Saponins, Flavonoids and Tannins while the quantitative analysis showed a higher value in the amount of saponin present in the extracts. Daily oral administration of the extracts (100 mg/kg) for the period of 21days shows that all the extracts significantly (p<0.05) decreased the levels of serum total Cholesterol and LDL-cholesterol. The atherogenic risk predictor indices also showed that root bark extract significantly (p<0.05) increased HDL-Cholesterol/total cholesterol ratio which may possess antiatherogenic effect and therefore these findings may be of clinical importance to individuals at risk of cardiovascular disease.
Keywords:
Atherogenic risk, Aqueous extract, phytotochemical, total Cholesterol and LDL-cholesterol, Vitex doniana,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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