Research Article | OPEN ACCESS
Effects of the Aqueous Extract of Clove (Syzygium aromaticum) on Wistar Rats
1Shama I.Y. Adam, 1Suha. B. Mohamed and 2Warda S. Abdelgadir
1Faculty of Science and Technology, El Neelain University, P.O. Box 12702, Khartoum, Sudan
2Food Research Centre, Ministry of Science and Communications, P.O. Box 213, Khartoum North, Sudan
British Journal of Pharmacology and Toxicology 2013 6:262-266
Received: September 14, 2013 | Accepted: September 21, 2013 | Published: December 25, 2013
Abstract
The present study was planned in order to investigate the effects of various oral doses of water extract of Syzygium aromaticum buds, emphases of its effect were placed on changes of the growth, serological, hematological and pathological characteristics of Wistar rats. Water extract of Syzygium aromaticum was fed to Wistar rats at 50, 200, 400 and 800 mg/kg/day for two weeks. Impairment of growth and hepatonephrotoxicity were observed in the rats of all groups. These changes were correlated with alterations in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities and total protein, cholesterol and urea concentration and hematology.
Keywords:
Hepatonephrotoxicity, Syzygium aromaticum, wistar rats,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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