Research Article | OPEN ACCESS
Lipid Lowering and Appetite Suppressive Effect of Leaves of Moringa oleifera Lam. in Rats
1Ijeoma Ogbuehi, 1Elias Adikwu and 2Deo Oputiri
1Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Choba, Rivers State
2College of Health Technology, Otuogidi-Ogbia, Bayelsa State, Nigeria
British Journal of Pharmacology and Toxicology 2014 3:111-116
Received: September 28, 2013 | Accepted: October 14, 2013 | Published: June 20, 2014
Abstract
This six-week study evaluates the effect of Moringa oleifera the lipid profile, body weight and appetite of adult male albino Wistar rats. The experimental rats were fed on a High Fat Diet (HFD) for four weeks and those found to be significantly hyperlipidemic were subdivided into five groups (A-E). Group A (control) received only distilled water; B, C, D received aqueous extract of M. oleifera leaves at varied doses of 100, 200 and 300 mg/kg, respectively; E were given the standard drug- atorvastatin (4 mg/kg, p.o.) along with the HFD. M. oleifera and atorvastatin were found to lower the serum cholesterol, triacylglyceride, VLDL, LDL, body weight and atherogenic index, but increased the HDL as compared to the HFD fed-untreated group (control). Interestingly too, it was found that the leaf extract did not precipitate high glucose and liver enzyme levels unlike those treated with the anti-hyperlipidemic drug. Extract exhibited a weight loss and appetite reducing property in the treated rats whist nourishing them as well. Thus, the study demonstrates that M. oleifera possesses a lipid lowering effect and also suppresses appetite, hence can be useful in the management of hyperlipidemia and associated health conditions.
Keywords:
Appetite, cholesterol, high fat diet, hyperlipidemia, Moringa oleifera, weight loss,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
|
|
![](http://www.maxwellsci.com/images/BJPT-maxw.jpg) |
ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
![Submit Manuscript](../images/sub.jpg) |
Information |
|
|
|
Sales & Services |
|
|
|