Research Article | OPEN ACCESS
Effects of Essential Oil Extracted from the Leaves of Hoslundia opposite V. on Selected Biochemical Indices in Rats
1J.O. Akolade, 2N.O. Muhammad, 3L.A. Usman, 4M.B. Odebisi, 5A.O. Sulyman and 6F.T. Akanji
1Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex, Sheda, Abuja
2Department of Biochemistry and Molecular Biology, Federal University, Dutsin-Ma
3Department of Chemistry
4Department of Microbiology, University of Ilorin, Ilorin
5Department of Biosciences and Biotechnology, Kwara State University, Malete, Ilorin
6Chemistry Advanced Laboratory, Sheda Science and Technology Complex, Sheda, Abuja, Nigeria
British Journal of Pharmacology and Toxicology 2014 3:117-122
Received: November 16, 2013 | Accepted: November 25, 2013 | Published: June 20, 2014
Abstract
Biochemical effect of essential oil extracted from the leaves of Hoslundia opposite on selected toxicological indices was evaluated. Twenty four Rattus norvegicus were randomly selected into four groups. The rats were treated with 110 and 220 mg/kg body weight (b.wt.) of the essential oil. All treatments were administered intraperitoneally, once a day for four days. The Alkaline phosphatase (ALP), alanine (ALT) and aspartate transaminases (AST) activities in the liver as well as kidney ALP and AST of the rats treated with the 110 and 220 mg/kg b. wt. of oil were significantly (p<0.05) lower, while the serum ALP and AST activities were higher compared to values in the non-treated rats. More so, the heart AST activities of rats treated with 220 mg/kg b. wt. of the oil were significantly (p<0.05) lower. However, serum protein, albumin, urea, total, conjugated bilirubin, ALT/AST and organ-body weight ratios were not significantly (p>0.05) altered, whereas serum creatinine concentrations were significantly (p<0.05) lower compared to those of non-treated control. Biochemical alterations observed in this study showed that the oil may not be completely safe when administered.
Keywords:
Enzymes, essential oil, Hoslundia opposite, rats, toxicity,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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