Abstract

Biochemical effect of essential oil extracted from the leaves of Hoslundia opposite on selected toxicological indices was evaluated. Twenty four Rattus norvegicus were randomly selected into four groups. The rats were treated with 110 and 220 mg/kg body weight (b.wt.) of the essential oil. All treatments were administered intraperitoneally, once a day for four days. The Alkaline phosphatase (ALP), alanine (ALT) and aspartate transaminases (AST) activities in the liver as well as kidney ALP and AST of the rats treated with the 110 and 220 mg/kg b. wt. of oil were significantly (p<0.05) lower, while the serum ALP and AST activities were higher compared to values in the non-treated rats. More so, the heart AST activities of rats treated with 220 mg/kg b. wt. of the oil were significantly (p<0.05) lower. However, serum protein, albumin, urea, total, conjugated bilirubin, ALT/AST and organ-body weight ratios were not significantly (p>0.05) altered, whereas serum creatinine concentrations were significantly (p<0.05) lower compared to those of non-treated control. Biochemical alterations observed in this study showed that the oil may not be completely safe when administered.

Keywords:

Enzymes, essential oil, Hoslundia opposite, rats, toxicity,

References

Competing interests

The authors have no competing interests.

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