Research Article | OPEN ACCESS
Probiotic Efficacy of Lactobacillus reuteri Culture Filtrates against Certain Groups of Proliferating Bacteria Isolated from Acne Abscess
Saud H. Al Motuirei and A.M.A. Saadabi
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Kingdom of Saudi Arabia
British Journal of Pharmacology and Toxicology 2014 2:106-110
Received: January 23, 2014 | Accepted: February 15, 2014 | Published: April 20, 2014
Abstract
Acne is a common disease in Saudi nationals particularly among adolescents and young adults. The disease has substantial effects on quality of life which making treatment essential. Probiotics nowadays is becoming a method of first choice to combat the disease. The present study was carried out to evaluate and to identify the causative agents of acne disease in Shaqra region. Subsequently, the effects of culture filtrate of the bacterium Lactobacillus reuteri on the in vitro growth of bacterial isolates obtained from acne i.e., Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes and Propionibacterium granulosum were also carried out along with the subsequent inhibitory impacts on acne symptomatology. It was observed that the culture filtrates of L. reuteri were significantly inhibitory to the growth of the four bacterial species. Increase in zone of inhibition was directly correlated with concentration of L. reuteri. L. reuteri at both diluted and concentrated doses was inhibitory at 24, 48 and 72 h of incubation periods. The most inhibitory incubation period was 48 h using well-diffusion agar technique with concentrated filtrate. The toxicity of the culture filtrate was largely influenced by the dilution and incubation period. Antibiotics sensitivity tests against different bacterial isolates was tested using Triclosan, Benzoyl peroxidase, Erythromycin, Retinoid, Tetracycline and Clindamycin. All of the bacterial isolates were vulnerable (susceptible, sensitive) to Triclosan and Benzoyl peroxidase, Retinoid, Tetracycline and Clindamycin, but all of the isolates were resistant to Erythromycin antibiotic. It could be concluded that the culture filtrate of L. reuteri could be used as probiotics and a source of biological control agents to cure acne disease in the area.
Keywords:
Acne, culture filtrates, kingdom of Saudi Arabia, Lactobacillus reuteri, probiotics,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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