Research Article | OPEN ACCESS
Effects of Silimarin and Curcumin against LPS-Induced Hepatotoxicity in Rats
1Sameh S. Gad, 2Ezzeddine El-Denshary and 1Amany I. El-Brairy
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, MSA University, Cairo, Egypt
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University,
Cairo, Egypt
British Journal of Pharmacology and Toxicology 2015 4:70-75
Received: April 19, 2015 | Accepted: May 10, 2015 | Published: October 20, 2015
Abstract
Hepatotoxicity is now receiving a supreme importance. LPS is the most potent activator of macrophages. The aim of this study is to demonstrate the prophylactic activity of silimarin and curcumin against LPS-induced hepatotoxicity in rats. The liver slices had been divided into 4 groups; normal, control (LPS), LPS+silimarin and LPS+curcumin (N = 12). After 24 h, analysis of ALT, GSH, TNF-&alpha and IL-10 was carried out. ALT in the control group showed a high significant elevation in comparison to the normal group, while group 3 and 4 showed a high significant decrease compared with the control group. In control (LPS) group a significant reduction in GSH level was observed; where in group 3 and 4 a significant increase was noticed in comparison to the control group. Control (LPS) group showed a high significant elevation in TNF-&alpha level in comparison to normal group, where in group 3 and 4 a high significant decrease was detected in comparison to the control group. Level of IL-10 in the control group indicated a high significant elevation compared to the normal group, while in group 3 and 4 a high significant decrease in the IL-10 levels were detected in comparison to the control group. In conclusion, silimarin and curcumin showed a hepatoprotective activity against hepatotoxicity induced by LPS.
Keywords:
Alanine amino Transferase (ALT), Curcumin, Precision Cut Liver Slices (PCLS), hepatotoxicity, Lipopolysaccharide (LPS), prophylaxis, reduced glutathione (GSH), silymarin, Tumor Necrosis Factor alpha (TNF-&alpha) lactate dehydrogenase (IL-10),
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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