Research Article | OPEN ACCESS
Analgesic, Anti-Inflammatory and Antipyretic Potential of the Stem Bark Extract of Stachytarpheta indica
1G.C. Akuodor, 1A.D. Essien, 2P.M. Udia, 3E. David-Oku, 4K.C. Chilaka, 1E.C. Asika and 1S.K. Nwadum
1Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State
University, Abakaliki
2Department of Pharmacology
3Department of Biochemistry, College of Medical Sciences, University of Calabar, Calabar
4Department of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikiwe University, Awka, Nigeria
British Journal of Pharmacology and Toxicology 2015 1:16-21
Received: October 29, 2014 | Accepted: December 27, 2014 | Published: February 20, 2015
Abstract
Aim of study: Stachytarpheta indica is used as herbal remedy for pains in Nigeria. Methods: To validate this claim, the analgesic, anti-inflammatory and antipyretic effects of the stem bark extract were examined in mice and rats by using acetic acid-induced writhing, tail immersion, xylene and egg albumin-induced paw oedema. While yeast and amphetamine induced pyrexia were used to study antipyretic activity in rats. LD50 of the stem bark extract was carried out to determine its safety. Results: The methanol stem bark extract of Stachytarpheta indica showed significant (p<0.05) dose dependent effect in the parameters assayed. The activity of the extract was comparable to acetylsalicylic acid and morphine respectively. The acute toxicity test was greater than 5000 mg/kg. Conclusions: It may be possible that the methanol stem bark extract of Stachytarpheta indica contains biologically active substances with potential value for the treatment of painful and feverish conditions.
Keywords:
Herbal medicine, , inflammation, , nociception, , pyrexia, , rats, , Stachytarpheta indica,
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Competing interests
The authors have no competing interests.
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