Research Article | OPEN ACCESS
In vitro Inhibition of Acetyl Cholinesterase, Lipoxygenase, Xanthine Oxidase and Antibacterial Activities of Five Indigofera (Fabaceae) Aqueous Acetone Extracts from Burkina Faso
1, 2S. Bakasso, 3A. Lamien-meda, 4C.E. Lamien, 2M. Kiendrebeogo, 2A.Y. Coulibaly, 2M. Compaore, 2N.R. Meda and 2O.G. Nacoulma
1Department of Chemistry, Faculty of Science and Technology, University of
Niamey (French), BP 10662, Niger
2Laboratory of Biochemistry and Applied Chemistry, UFR/SVT University of
Ouagadougou (French), 03 BP 7021 Ouagadougou 03, Burkina Faso
3Institute for Applied Botany and Pharmacognosy, University of Veterinary
Medicine Vienna, Veterin
4Animal Production Unit, FAO/IAEA Agriculture and Biotechnology Laboratory, IAEA, Vienna, Austria
Current Research Journal of Biological Sciences 2013 3:115-122
Received: November 24, 2012 | Accepted: February 08, 2013 | Published: May 20, 2013
Abstract
The aim of this study is to evaluate the inhibition of oxidative stress related enzymes of aqueous acetone extracts, as well as antibacterial activity from five Indigofera species well-known medicinal plant from Burkina. Also are investigated in this study the potential contribution of tannins and of flavonol in these activities Particularly, aqueous acetone extracts were investigated for their Lipoxygenase (LOX), Xanthine Oxidase (XO) and Acetylcholinesterase (AChE) inhibitions that are implied in inflammation, gout and Alzheimer’s etiology diseases. Interestingly, I. macrocalyx which had the highest flavonol content (of all) showed more inhibition against LOX and XO (51.16 and 77.33% respectively). Our study showed a significant correlation between XO inhibition and total flavonol content (R2 = 0.9052). AChE was low sensible to all extracts. In contrast, the extracts were rich in tannin compounds especially in I. tinctoria extract. And results of the in vitro antibacterial activities of these extracts against five bacteria showed that all bacteria were sensible to all extracts particularly S. typhimurium and B. cereus. Our results suggest that the five studied species prove to be good sources of inhibition of the three enzymes involved in oxidative stress and also to have some antibacterial properties. That is what probably explains their uses in folk medicine, singularly, in the treatment of gout, dysentery and anti-inflammatory diseases.
Keywords:
Bacterial, Burkina Faso, enzymes inhibition, flavonol, Indigofera, tannin,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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